实用药物与临床
實用藥物與臨床
실용약물여림상
Practical Pharmacy and Clinical Remedies
2015年
11期
1339-1342
,共4页
缺血性肠炎%低分子肝素钠%凝血功能%临床特征
缺血性腸炎%低分子肝素鈉%凝血功能%臨床特徵
결혈성장염%저분자간소납%응혈공능%림상특정
Ischemic colitis%Low molecular weight heparin sodium%Blood coagulation function%Clinical character-istics
目的 探讨缺血性肠炎( IC)患者的凝血功能改变以及低分子肝素钠( LMWH)在不同临床特征的IC患者中的疗效. 方法 收集、分析2012年7月至2014年7月在我院接受治疗的IC患者的临床资料,并选取30例年龄相近的体检者作为对照组. 比较两组受试者的基线资料和凝血功能,并探讨LMWH在观察组患者中的疗效、不良反应以及不同临床特征所对应的凝血功能改变. 结果 观察组PT、APTT水平显著低于对照组,而D-二聚体、纤维蛋白原水平显著高于对照组( P<0. 01 );坏疽型患者的PT、APTT低于非坏疽型患者,而D-二聚体、纤维蛋白原水平更高(P<0. 05);与病变≤2处的患者比较,病变>2处的患者PT、APTT水平更低,而D-二聚体、纤维蛋白原更高( P均<0. 05 );与治疗前比较,不同临床特征的患者治疗后的PT、APTT水平均明显升高, D-二聚体、纤维蛋白原水平明显降低(P<0. 05);观察组不同病变分型、数量所对应的疗效和不良反应比较差异均无统计学意义(P>0. 05). 结论 LMWH在不同病变分型、病变数量的IC患者中均有确切的疗效,均能够显著改善患者的高凝状态.
目的 探討缺血性腸炎( IC)患者的凝血功能改變以及低分子肝素鈉( LMWH)在不同臨床特徵的IC患者中的療效. 方法 收集、分析2012年7月至2014年7月在我院接受治療的IC患者的臨床資料,併選取30例年齡相近的體檢者作為對照組. 比較兩組受試者的基線資料和凝血功能,併探討LMWH在觀察組患者中的療效、不良反應以及不同臨床特徵所對應的凝血功能改變. 結果 觀察組PT、APTT水平顯著低于對照組,而D-二聚體、纖維蛋白原水平顯著高于對照組( P<0. 01 );壞疽型患者的PT、APTT低于非壞疽型患者,而D-二聚體、纖維蛋白原水平更高(P<0. 05);與病變≤2處的患者比較,病變>2處的患者PT、APTT水平更低,而D-二聚體、纖維蛋白原更高( P均<0. 05 );與治療前比較,不同臨床特徵的患者治療後的PT、APTT水平均明顯升高, D-二聚體、纖維蛋白原水平明顯降低(P<0. 05);觀察組不同病變分型、數量所對應的療效和不良反應比較差異均無統計學意義(P>0. 05). 結論 LMWH在不同病變分型、病變數量的IC患者中均有確切的療效,均能夠顯著改善患者的高凝狀態.
목적 탐토결혈성장염( IC)환자적응혈공능개변이급저분자간소납( LMWH)재불동림상특정적IC환자중적료효. 방법 수집、분석2012년7월지2014년7월재아원접수치료적IC환자적림상자료,병선취30례년령상근적체검자작위대조조. 비교량조수시자적기선자료화응혈공능,병탐토LMWH재관찰조환자중적료효、불량반응이급불동림상특정소대응적응혈공능개변. 결과 관찰조PT、APTT수평현저저우대조조,이D-이취체、섬유단백원수평현저고우대조조( P<0. 01 );배저형환자적PT、APTT저우비배저형환자,이D-이취체、섬유단백원수평경고(P<0. 05);여병변≤2처적환자비교,병변>2처적환자PT、APTT수평경저,이D-이취체、섬유단백원경고( P균<0. 05 );여치료전비교,불동림상특정적환자치료후적PT、APTT수평균명현승고, D-이취체、섬유단백원수평명현강저(P<0. 05);관찰조불동병변분형、수량소대응적료효화불량반응비교차이균무통계학의의(P>0. 05). 결론 LMWH재불동병변분형、병변수량적IC환자중균유학절적료효,균능구현저개선환자적고응상태.
Objective To analyze the change of blood coagulation function in ischemic colitis ( IC) patients and the efficacy of LMWH for IC patients with different clinical characteristics. Methods Clinical data of IC patients received treatment in our hospital from July 2012 to July 2014 was collected and analyzed,and 30 normal people were selected as control group. The general information and blood coagulation function were analyzed between the two groups. The efficacy,adverse reaction and effect of LMWH on the blood coagulation function in IC patients with differ-ent clinical characteristics were observed. Results The levels of PT and APTT of observation group were lower than those of control group,and D-dimer and fibrinogen were higher than those of control group (P<0. 01). Patients with necrosis had the lower levels of PT and APTT with higher levels of D-dimer and fibrinogen than patients without necro-sis in observation group (P<0. 05). Compared with patients with less than 2 lesions,patients with more than 2 lesions have lower levels of PT,APTT and higher levels of D-dimer and fibrinogen. Conclusion LMWH has a definite effica-cy in IC patients with different pathological types and lesions,and it could significantly improve the hypercoagulable states.
