CAJ | 학술논문

目的观察复方甘草酸苷对寻常型银屑病患者Th17细胞相关因子表达的影响. 方法选择我院皮肤科病房2011年4月至2014年10月期间确诊为寻常型银屑病的患者共计35例,按照具体用药治疗情况,分为2组. 复方甘草酸苷组(19例),在常规用药基础上同时静脉滴注复方甘草酸苷1次/d,每次40 mL,共计4周;常规治疗组(16例)给予抗组胺药、外用维生素E乳膏等药物治疗;对照组(22例)为本院体检中心健康人群.检测三组外周血中IL-17、IL-23和IL-22的表达水平. 结果银屑病患者与健康对照组相比,外周血中IL-17、IL-23和IL-22水平明显升高,差异有统计学意义(P<0. 05);复方甘草酸苷和常规治疗均可降低外周血中IL-17、IL-23和IL-22的表达水平,治疗前后自身对比差异有统计学意义( P<0. 05 );复方甘草酸苷和常规治疗相比,外周血中IL-17、IL-23和IL-22的表达降低更明显,差异有统计学意义(P<0. 05). 结论 Th17细胞相关因子可作为判断寻常型银屑病的指标,复方甘草酸苷治疗寻常型银屑病较常规治疗更有效.
목적 관찰복방감초산감대심상형은설병환자Th17세포상관인자표체적영향. 방법 선택아원피부과병방2011년4월지2014년10월기간학진위심상형은설병적환자공계35례,안조구체용약치료정황,분위2조. 복방감초산감조(19례),재상규용약기출상동시정맥적주복방감초산감1차/d,매차40 mL,공계4주;상규치료조(16례)급여항조알약、외용유생소E유고등약물치료;대조조(22례)위본원체검중심건강인군.검측삼조외주혈중IL-17、IL-23화IL-22적표체수평. 결과 은설병환자여건강대조조상비,외주혈중IL-17、IL-23화IL-22수평명현승고,차이유통계학의의(P<0. 05);복방감초산감화상규치료균가강저외주혈중IL-17、IL-23화IL-22적표체수평,치료전후자신대비차이유통계학의의( P<0. 05 );복방감초산감화상규치료상비,외주혈중IL-17、IL-23화IL-22적표체강저경명현,차이유통계학의의(P<0. 05). 결론 Th17세포상관인자가작위판단심상형은설병적지표,복방감초산감치료심상형은설병교상규치료경유효.
Objective To observe the effect of compound glycyrrhizin on the expression of Th17 cells related factors in patients with psoriasis vulgaris. Methods Thirty-five patients diagnosed as psoriasis vulgaris in dermatology department in our hospital from April 2011 to October 2014 were divided into 2 groups according to the specific drug treatment. Compound glycyrrhizin group ( n=19 ) received intravenous infusion of compound glycyrrhizin once daily (40 mL),for 4 weeks on the basis of the conventional treatment. Treatment group (n=16) was given antihistamines, topical vitamin E cream,and so on. Control group (n=22) enrolled healthy people from the health examination cen-ter. IL-17,IL-23 and IL-22 level in peripheral blood of the three groups were detected and compared. Results Before treathent,the IL-17,IL-23 and IL-22 levels in peripheral blood of psoriasis patients were significantly higher than those of cntrol group(P<0. 05);After compound glycyrrhizin and routine treatment,the peripheral blood levels of IL-17,IL-23 and IL-22 decreased,there were significant differences (P<0. 05);the levels of IL-17,IL-23 and IL-22 in peripher-al blood in compound glycyrrhizin group decreased more obviously than those of routine treatment group (P<0. 05). Conclusion Th17 cell related factors can be used as an indicator of psoriasis vulgaris. Compound glycyrrhizin is more effective than conventional therapy in the treatment of vulgaris psoriasis.