CAJ | 학술논문

目的探讨过氧化物酶体增殖物激活受体δ( PPARD)基因rs2016520位点多态性对那格列奈治疗2型糖尿病患者疗效的影响. 方法选取新诊断的2型糖尿病患者60例,接受那格列奈单药治疗8 周,治疗前后检测糖脂代谢相关指标. 用PCR限制性片段长度多态性( RFLP)法测定基因多态性,根据不同基因型分组比较药效. 结果 60 例新诊断 2 型糖尿病患者完成了 8 周随访,那格列奈治疗后, FPG、PPG、FINS、PINS、HbA1c、TC和TG均显著改善(P<0. 05);TT基因型患者PPG降低值高于携带C等位基因的患者(P<0. 05).结论那格列奈治疗2型糖尿病患者疗效显著;PPARD基因rs2016520位点多态性可影响那格列奈的疗效,那格列奈对TT基因型患者的降糖作用优于携带C等位基因的患者.
목적 탐토과양화물매체증식물격활수체δ( PPARD)기인rs2016520위점다태성대나격렬내치료2형당뇨병환자료효적영향. 방법 선취신진단적2형당뇨병환자60례,접수나격렬내단약치료8 주,치료전후검측당지대사상관지표. 용PCR한제성편단장도다태성( RFLP)법측정기인다태성,근거불동기인형분조비교약효. 결과 60 례신진단 2 형당뇨병환자완성료 8 주수방,나격렬내치료후, FPG、PPG、FINS、PINS、HbA1c、TC화TG균현저개선(P<0. 05);TT기인형환자PPG강저치고우휴대C등위기인적환자(P<0. 05).결론 나격렬내치료2형당뇨병환자료효현저;PPARD기인rs2016520위점다태성가영향나격렬내적료효,나격렬내대TT기인형환자적강당작용우우휴대C등위기인적환자.
Objective To investigate the effect of peroxisome proliferator-activated receptorδ( PPARD) gene rs2016520 polymorphism on the response to therapy with nateglinide in type 2 diabetic patients. Methods Sixty newly diagnosed type 2 diabetic patients received nateglinide monotherapy fer 8 weeks,the glucose and lipid metabolism relat-ed indicators were detected before and after treatment. Gene polymorphism were detected by PCR-restriction fragment length polymorphism ( RFLP) ,the efficacy of different genotypes was compared. Results All the patients with type 2 diabetes accomplished 8 weeks follow-up visits,the FPG,PPG,FINS,PINS,HbA1c,TC and TG were significantly im-proved (P<0. 05)after nateglinide treatment;patients with TT genotype had more decrease in PPG than the patients carrying C allele (P<0. 05). Conclusion Nateglinide is effective for type 2 diabetes;PPARD rs2016520 gene poly-morphism can affect the efficacy of nateglinide,the patients carrying C allele have poor response to natelinide efficacy as measured by PPG levels than the patients with TT genotype.