中华胃肠外科杂志
中華胃腸外科雜誌
중화위장외과잡지
Chinese Journal of Gastrointestinal Surgery
2015年
11期
1154-1157
,共4页
曾长青%黄良祥%郑羽%黄海啸%陈林昊%池良杰
曾長青%黃良祥%鄭羽%黃海嘯%陳林昊%池良傑
증장청%황량상%정우%황해소%진림호%지량걸
结肠肿瘤%PDZ结合域转录共激活因子%Hippo信号通路%临床病理因素%预后
結腸腫瘤%PDZ結閤域轉錄共激活因子%Hippo信號通路%臨床病理因素%預後
결장종류%PDZ결합역전록공격활인자%Hippo신호통로%림상병리인소%예후
Colonic neoplasms%Transcriptional coactivator with PDZ-binding motif%Hippo signaling pathway%Clinicopathological features%Prognosis
目的 探讨结肠癌组织中PDZ结合域转录共激活因子(TAZ蛋白)的表达及其与患者临床病理特征及预后的关系.方法 采用免疫组织化学法检测56例结肠癌及对应癌旁组织中TAZ蛋白表达情况,比较不同病理特征患者TAZ的阳性表达率,并分析其表达与结肠癌患者生存预后的关系.结果 TAZ蛋白表达主要定位于细胞核,其在结肠癌组织中的阳性率明显高于对应癌旁组织[73.2％(41/56)比12.5％(7/56),P=0.000].TAZ蛋白在结肠癌组织中的表达与肿瘤大小(P=0.009)、浸润深度(P=0.026)、淋巴结转移(P=0.034)和TNM分期(P=0.002)有关.TAZ阴性表达患者5年生存率明显高于阳性表达患者(66.7％比22.9％,P=0.0017).多因素回归分析显示,TAZ蛋白阳性表达是影响患者预后的独立因素[HR(95％CI):3.532(1.266～9.858),P=0.016].结论 TAZ蛋白在结肠癌组织中的表达异常升高,且与结肠癌患者不良预后相关.
目的 探討結腸癌組織中PDZ結閤域轉錄共激活因子(TAZ蛋白)的錶達及其與患者臨床病理特徵及預後的關繫.方法 採用免疫組織化學法檢測56例結腸癌及對應癌徬組織中TAZ蛋白錶達情況,比較不同病理特徵患者TAZ的暘性錶達率,併分析其錶達與結腸癌患者生存預後的關繫.結果 TAZ蛋白錶達主要定位于細胞覈,其在結腸癌組織中的暘性率明顯高于對應癌徬組織[73.2％(41/56)比12.5％(7/56),P=0.000].TAZ蛋白在結腸癌組織中的錶達與腫瘤大小(P=0.009)、浸潤深度(P=0.026)、淋巴結轉移(P=0.034)和TNM分期(P=0.002)有關.TAZ陰性錶達患者5年生存率明顯高于暘性錶達患者(66.7％比22.9％,P=0.0017).多因素迴歸分析顯示,TAZ蛋白暘性錶達是影響患者預後的獨立因素[HR(95％CI):3.532(1.266～9.858),P=0.016].結論 TAZ蛋白在結腸癌組織中的錶達異常升高,且與結腸癌患者不良預後相關.
목적 탐토결장암조직중PDZ결합역전록공격활인자(TAZ단백)적표체급기여환자림상병리특정급예후적관계.방법 채용면역조직화학법검측56례결장암급대응암방조직중TAZ단백표체정황,비교불동병리특정환자TAZ적양성표체솔,병분석기표체여결장암환자생존예후적관계.결과 TAZ단백표체주요정위우세포핵,기재결장암조직중적양성솔명현고우대응암방조직[73.2％(41/56)비12.5％(7/56),P=0.000].TAZ단백재결장암조직중적표체여종류대소(P=0.009)、침윤심도(P=0.026)、림파결전이(P=0.034)화TNM분기(P=0.002)유관.TAZ음성표체환자5년생존솔명현고우양성표체환자(66.7％비22.9％,P=0.0017).다인소회귀분석현시,TAZ단백양성표체시영향환자예후적독립인소[HR(95％CI):3.532(1.266～9.858),P=0.016].결론 TAZ단백재결장암조직중적표체이상승고,차여결장암환자불량예후상관.
Objective To investigate the expression of transcriptional coactivator with PDZ-binding motif (TAZ) in colon cancer tissues and its association with clinicopathological parameters and prognosis of patients.Methods The expression of TAZ protein was detected in 56 resected colon cancer tissues and matched tumor-adjacent tissues using immunohistochemistry.The positive expression rate of TAZ was compared between patients with different clinicopathological features.The association between TAZ expression and prognosis was analyzed.Results Expression of TAZ protein located in the nucleolus.The positive expression rate of TAZ in colon cancer tissues was significantly higher than that in matched tumor-adjacent tissues (73.2％ vs.12.5％, P=0.000).Clinicopathological evaluation suggested that the expression of TAZ protein was associated with tumor size (P=0.009), depth of infiltration (P=0.026), lymph node metastasis (P=0.007) and TNM staging (P=0.004).Colon cancer patients with negative expression of TAZ showed a better 5-year survival as compared with those with positive expression of TAZ (66.7％ vs.22.9％, P=0.0017).Multivariate Cox regression analysis revealed that positive TAZ expression was an independent factor for predicting poor prognosis in colon cancer (HR:3.532, 95％ CI: 1.3-9.9, P=0.016).Conclusion The expression of TAZ protein is up-regulated in colon cancer tissues and its high expression is associated with poor prognosis of colon cancer patients.
