中华普通外科学文献（电子版）
中華普通外科學文獻（電子版）
중화보통외과학문헌（전자판）
Chinese Archives of General Surgery(Electronic Edition)
2015年
6期
463-466
,共4页
胃癌%进展期%新辅助化疗%肠道营养%细胞增殖活性%免疫水平%营养
胃癌%進展期%新輔助化療%腸道營養%細胞增殖活性%免疫水平%營養
위암%진전기%신보조화료%장도영양%세포증식활성%면역수평%영양
Gastric cancer%Progressive stage%Neoadjuvant chemotherapy%Enteral nutrition%Cell proliferative activity%Immunity level%Nutrition
目的 探讨术前新辅助化疗结合肠内营养对胃癌患者肿瘤细胞增殖活性的影响效果.方法 将2012年7月至2014年7月收治的132例进展期胃癌患者,随机分为观察组(术前新辅助化疗联合肠内营养)和对照组(单纯予以新辅助化疗),各66例,采用流式细胞仪检测两组患者肿瘤标本的细胞增殖情况,通过CD4、CD8、CD4/CD8、NK细胞的检测评价两组患者的免疫功能,检测血清学指标以及营养风险筛查(NRS评分)进行营养评价.结果 治疗前,两组患者的肿瘤细胞增殖活性、免疫指标、营养状况均差异无统计学意义.治疗后,观察组患者的CD4、CD4/CD8、NK、总蛋白、白蛋白、前白蛋白、转铁蛋白、血红蛋白均较对照组增加明显,DI、SPF、PI、CD8、NRS评分降低明显,差异有统计学意义(P<0.05).结论 术前新辅助化疗结合肠内营养可较好地降低肿瘤细胞的增殖活性,改善其免疫水平及营养状况.
目的 探討術前新輔助化療結閤腸內營養對胃癌患者腫瘤細胞增殖活性的影響效果.方法 將2012年7月至2014年7月收治的132例進展期胃癌患者,隨機分為觀察組(術前新輔助化療聯閤腸內營養)和對照組(單純予以新輔助化療),各66例,採用流式細胞儀檢測兩組患者腫瘤標本的細胞增殖情況,通過CD4、CD8、CD4/CD8、NK細胞的檢測評價兩組患者的免疫功能,檢測血清學指標以及營養風險篩查(NRS評分)進行營養評價.結果 治療前,兩組患者的腫瘤細胞增殖活性、免疫指標、營養狀況均差異無統計學意義.治療後,觀察組患者的CD4、CD4/CD8、NK、總蛋白、白蛋白、前白蛋白、轉鐵蛋白、血紅蛋白均較對照組增加明顯,DI、SPF、PI、CD8、NRS評分降低明顯,差異有統計學意義(P<0.05).結論 術前新輔助化療結閤腸內營養可較好地降低腫瘤細胞的增殖活性,改善其免疫水平及營養狀況.
목적 탐토술전신보조화료결합장내영양대위암환자종류세포증식활성적영향효과.방법 장2012년7월지2014년7월수치적132례진전기위암환자,수궤분위관찰조(술전신보조화료연합장내영양)화대조조(단순여이신보조화료),각66례,채용류식세포의검측량조환자종류표본적세포증식정황,통과CD4、CD8、CD4/CD8、NK세포적검측평개량조환자적면역공능,검측혈청학지표이급영양풍험사사(NRS평분)진행영양평개.결과 치료전,량조환자적종류세포증식활성、면역지표、영양상황균차이무통계학의의.치료후,관찰조환자적CD4、CD4/CD8、NK、총단백、백단백、전백단백、전철단백、혈홍단백균교대조조증가명현,DI、SPF、PI、CD8、NRS평분강저명현,차이유통계학의의(P<0.05).결론 술전신보조화료결합장내영양가교호지강저종류세포적증식활성,개선기면역수평급영양상황.
Objective To discuss the effect of preoperative neoadjuvant chemotherapy combined with enteral nutrition for gastric cancer patientstumor cell proliferative activity. Methods One hundred and thirty-two gastric cancer patients in progressive stage were selected and divided randomly into obser-vation group (preoperative neoadjuvant chemotherapy combined with enteral nutrition), and control group (simply preoperative neoadjuvant chemotherapy). All patients were recorded for and compared in tumor cell proliferative activity, immunity level and nutrition improvement before and after therapy. Results Before therapy, there was no difference between two group in tumor cell proliferative activity, immunity index, and nutriture. After therapy, compared with control group, CD4, CD4/CD8, NK, total pro-tein, albumin, prealbumin, transferring, and hemoglobin all obviously increased in observation group, while DI, SPF, PI, CD8, NRS scores obviously decreased; the differences had statistical significance (P<0.05). Conclusion Preoperative neoadjuvant chemotherapy combined with enteral nutrition can decrease tumor cell proliferative activity in gastric cancer patients, and improve their immunity level and nutrition.
