中华普通外科学文献（电子版）
中華普通外科學文獻（電子版）
중화보통외과학문헌（전자판）
Chinese Archives of General Surgery(Electronic Edition)
2015年
6期
437-440
,共4页
李新%田蜜%王程%王梅%任辉明
李新%田蜜%王程%王梅%任輝明
리신%전밀%왕정%왕매%임휘명
胃肿瘤%螺杆菌,幽门%CD14%多态性%易感性%交互作用
胃腫瘤%螺桿菌,幽門%CD14%多態性%易感性%交互作用
위종류%라간균,유문%CD14%다태성%역감성%교호작용
Stomach neoplasms%Helicobacter pylori%CD14%Polymorphism%Susceptibility%Inter-action
目的 探讨荆门地区人群CD14-159C/T多态性与胃癌关联性及其与幽门螺杆菌交互作用.方法 采用多聚酶链反应-限制性片段长度多态性(PCR-RFLP)方法,分析127例胃癌患者和127名健康者的CD14-159C/T基因型.非条件Logistic分析各基因型与发病中易感性关系以及与幽门螺杆菌的交互作用.结果 携带C(CC/CT)基因个体患病风险较非C基因携带者(TT)风险明显增加(OR=1.35,95% CI=1.22~2.56,P=0.000;校正OR=1.61,95% CI =1.21~3.01,P=0.000).条件Logistic分析表明,携带CC/CT基因型幽门螺杆菌个体胃癌罹患风险是携带TT基因非幽门螺杆菌个体的3.39倍(OR=3.39,95% CI =2.66~5.36,P=0.000)(RERI=1.94,95% CI=1.41~2.77;API=0.59,95%CI=0.33~0.84;S=1.46,95%CI=1.37~2.66).结论 CD14-159C/T多态性增加荆门地区个体胃癌的罹患风险,且与幽门螺杆菌在胃癌发病中存在协同效应.
目的 探討荊門地區人群CD14-159C/T多態性與胃癌關聯性及其與幽門螺桿菌交互作用.方法 採用多聚酶鏈反應-限製性片段長度多態性(PCR-RFLP)方法,分析127例胃癌患者和127名健康者的CD14-159C/T基因型.非條件Logistic分析各基因型與髮病中易感性關繫以及與幽門螺桿菌的交互作用.結果 攜帶C(CC/CT)基因箇體患病風險較非C基因攜帶者(TT)風險明顯增加(OR=1.35,95% CI=1.22~2.56,P=0.000;校正OR=1.61,95% CI =1.21~3.01,P=0.000).條件Logistic分析錶明,攜帶CC/CT基因型幽門螺桿菌箇體胃癌罹患風險是攜帶TT基因非幽門螺桿菌箇體的3.39倍(OR=3.39,95% CI =2.66~5.36,P=0.000)(RERI=1.94,95% CI=1.41~2.77;API=0.59,95%CI=0.33~0.84;S=1.46,95%CI=1.37~2.66).結論 CD14-159C/T多態性增加荊門地區箇體胃癌的罹患風險,且與幽門螺桿菌在胃癌髮病中存在協同效應.
목적 탐토형문지구인군CD14-159C/T다태성여위암관련성급기여유문라간균교호작용.방법 채용다취매련반응-한제성편단장도다태성(PCR-RFLP)방법,분석127례위암환자화127명건강자적CD14-159C/T기인형.비조건Logistic분석각기인형여발병중역감성관계이급여유문라간균적교호작용.결과 휴대C(CC/CT)기인개체환병풍험교비C기인휴대자(TT)풍험명현증가(OR=1.35,95% CI=1.22~2.56,P=0.000;교정OR=1.61,95% CI =1.21~3.01,P=0.000).조건Logistic분석표명,휴대CC/CT기인형유문라간균개체위암리환풍험시휴대TT기인비유문라간균개체적3.39배(OR=3.39,95% CI =2.66~5.36,P=0.000)(RERI=1.94,95% CI=1.41~2.77;API=0.59,95%CI=0.33~0.84;S=1.46,95%CI=1.37~2.66).결론 CD14-159C/T다태성증가형문지구개체위암적리환풍험,차여유문라간균재위암발병중존재협동효응.
Objective To study the relationship between CD14-159C/T polymorphism and sus-ceptibility to gastric cancer and their interaction with Helicobacter pylori in Jingmen district. Methods Genotypes of 127 patients with gastric cancer and 127 healthy subjects were examined by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). The unconditional Logistic regression (ULR) was performed to assess the gastric cancer risk and interaction with Helicobacter pylori. Results There was increased risk of developing gastric cancer for CC/CT genotype carriers compared with TT genotype carriers (OR=1.35, 95% CI=1.22-2.56, P=0.000; Adjusted OR=1.61, 95% CI=1.21-3.01, P=0.000). By using the ULR method, Helicobacter pylori-positive subjects with genotype CT/CC were at a risk of 3.39 times higher than that of Helicobacter pylori-negative subjects with genotype TT (OR=3.39, 95% CI=2.66-5.36, P=0.000) (RERI=1.94, 95% CI=1.41-2.77; API=0.59, 95% CI=0.33-0.84; S=1.46, 95% CI=1.37-2.66). Conclusion CD14-159C/T polymorphism is associated with in-creased risk for gastric cancer, and its interaction with Helicobacter pylori has synergistic effects on risk of gastric cancer in Jingmen district.
