CAJ | 학술논문

目的了解临床分离的粪肠球菌耐利奈唑胺株对利奈唑胺的耐药情况以及耐利唑胺株对常用抗菌药物的耐药谱. 方法用美国临床实验室标准化委员会推荐的方法,筛选出粪肠球菌666 株,用K-B纸片扩散法检测粪肠球菌对利奈唑胺的敏感性,检测利奈唑胺耐药株对7 种临床常用抗菌药物的耐药性.结果 666株粪肠球菌中,共检出28株对利奈唑胺耐药菌株,耐药率为4.2%;耐利奈唑胺的粪肠球菌对喹奴普丁/达福普汀、四环素、红霉素和环丙沙星的耐药率分别为100.0%,85.7%,78.6%和50.0%,但对阿莫西林敏感;28株耐利奈唑胺株中只有1株耐万古霉素,但有17 株( 60.7%)为万古霉素中介耐药;对庆大霉素高水平耐药率仅为3.6%. 结论粪肠球菌已出现对利奈唑胺的耐药,但氨基糖苷类联合青霉素类药物仍然对利奈唑胺耐药的粪肠球菌具有体外抗菌活性.
목적 료해림상분리적분장구균내리내서알주대리내서알적내약정황이급내리서알주대상용항균약물적내약보. 방법 용미국림상실험실표준화위원회추천적방법,사선출분장구균666 주,용K-B지편확산법검측분장구균대리내서알적민감성,검측리내서알내약주대7 충림상상용항균약물적내약성.결과 666주분장구균중,공검출28주대리내서알내약균주,내약솔위4.2%;내리내서알적분장구균대규노보정/체복보정、사배소、홍매소화배병사성적내약솔분별위100.0%,85.7%,78.6%화50.0%,단대아막서림민감;28주내리내서알주중지유1주내만고매소,단유17 주( 60.7%)위만고매소중개내약;대경대매소고수평내약솔부위3.6%. 결론 분장구균이출현대리내서알적내약,단안기당감류연합청매소류약물잉연대리내서알내약적분장구균구유체외항균활성.
Objective To explore the condition of various types of anti-biotic resistance of enterococcus isolated in clinical.Methods Agar dilu-tion method and K-B paper diffusion method had been used to test the drug susceptibility of minimum inhibitory concentration ( MIC ) of entero-coccus isolated in clinical and to measure its minimum antibacterial depth.Results A total of 666 strains of enterococcus faecalis were isola-ted from a variety of clinical specimens, and 28 strains were linezolid re-sistance.Among these 28 linezolid resistance strains, the drug resist-ances to quinupristin, tetracyclinet, erythromycin and ciprofloxacin were 100%, 85.7%, 78.6%and 50.0%, respectively.All strains were sen-sitive to amoxicillin, 1 strains were resistant to vancomycin, 17 strains (60.7%) were intermediary resistance to vancomycin, high-level re-sistance to gentamicin was 3.6%.Conclusion Enterococcus faecalis had appeared resistance to linezolid, but the combination of aminoglyco-side and penicillins still has antibacterial activity in vitro to linezolid re-sistant enterococcus faecalis.