中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
The Chinese Journal of Clinical Pharmacology
2015年
22期
2220-2222
,共3页
米非司酮%米索前列醇%终止妊娠%不良反应
米非司酮%米索前列醇%終止妊娠%不良反應
미비사동%미색전렬순%종지임신%불량반응
mifepristone%misoprostol%termination of pregnancy%adverse reaction
目的 探讨米索前列醇不同给药方式终止中期妊娠的临床疗效及安全性.方法 66例中期妊娠要求终止妊娠的孕妇随机分为对照组31例和试验组35例. 试验组口服米非司酮100 mg·d-1 ,连服2 d,第3天晨起阴道内放置米索前列醇0.6 mg,如未分娩,则每12 h给药0.4 mg,重复不超过4次;对照组口服米非司酮100 mg·d-1 ,连服2 d,第3天晨起空腹口服米索前列醇0.4 mg,如未分娩,则每3 h给药0.4 mg,重复不超过4次. 比较2组患者的总有效率、引产时间、产后出血量、阴道出血时间及米索前列醇用量. 结果 对照组总有效率为93.54%,试验组为100.00%( P>0.05 ). 试验组引产时间、产后2 h出血量及米索前列醇用量显著低于对照组( P<0.05 ) ,阴道出血时间差异无统计学意义( P>0.05 ).试验组终止妊娠期间发生恶心呕吐13例,发热2例,皮疹1例;对照组发生恶心呕吐12例,发热1例,2组不良反应发生率差异无统计学意义( P>0.05). 结论 米非司酮联合米索前列醇终止中期妊娠临床疗效确切,且经阴道给药效果较好.
目的 探討米索前列醇不同給藥方式終止中期妊娠的臨床療效及安全性.方法 66例中期妊娠要求終止妊娠的孕婦隨機分為對照組31例和試驗組35例. 試驗組口服米非司酮100 mg·d-1 ,連服2 d,第3天晨起陰道內放置米索前列醇0.6 mg,如未分娩,則每12 h給藥0.4 mg,重複不超過4次;對照組口服米非司酮100 mg·d-1 ,連服2 d,第3天晨起空腹口服米索前列醇0.4 mg,如未分娩,則每3 h給藥0.4 mg,重複不超過4次. 比較2組患者的總有效率、引產時間、產後齣血量、陰道齣血時間及米索前列醇用量. 結果 對照組總有效率為93.54%,試驗組為100.00%( P>0.05 ). 試驗組引產時間、產後2 h齣血量及米索前列醇用量顯著低于對照組( P<0.05 ) ,陰道齣血時間差異無統計學意義( P>0.05 ).試驗組終止妊娠期間髮生噁心嘔吐13例,髮熱2例,皮疹1例;對照組髮生噁心嘔吐12例,髮熱1例,2組不良反應髮生率差異無統計學意義( P>0.05). 結論 米非司酮聯閤米索前列醇終止中期妊娠臨床療效確切,且經陰道給藥效果較好.
목적 탐토미색전렬순불동급약방식종지중기임신적림상료효급안전성.방법 66례중기임신요구종지임신적잉부수궤분위대조조31례화시험조35례. 시험조구복미비사동100 mg·d-1 ,련복2 d,제3천신기음도내방치미색전렬순0.6 mg,여미분면,칙매12 h급약0.4 mg,중복불초과4차;대조조구복미비사동100 mg·d-1 ,련복2 d,제3천신기공복구복미색전렬순0.4 mg,여미분면,칙매3 h급약0.4 mg,중복불초과4차. 비교2조환자적총유효솔、인산시간、산후출혈량、음도출혈시간급미색전렬순용량. 결과 대조조총유효솔위93.54%,시험조위100.00%( P>0.05 ). 시험조인산시간、산후2 h출혈량급미색전렬순용량현저저우대조조( P<0.05 ) ,음도출혈시간차이무통계학의의( P>0.05 ).시험조종지임신기간발생악심구토13례,발열2례,피진1례;대조조발생악심구토12례,발열1례,2조불량반응발생솔차이무통계학의의( P>0.05). 결론 미비사동연합미색전렬순종지중기임신림상료효학절,차경음도급약효과교호.
Objective To evaluate the clinical efficacy and safety of mi-soprostol in termination of pregnancy by different administrations. Methods Sixty-six pregnant women who want to end pregnancy were randomly divided into control group ( n =31 ) and experiment group (n=35).Experiment group received oral mifepristone 100 mg·d -1 for 2 days.On the third day morning intravaginal misoprostol 0.6 mg, if not childbirth , every 12 h administration misoprostol 0.4 mg, repeat no more than 4 times; control group was treated with oral mifepristone 100 mg·d-1 for 2 day, on the third day morning oral misoprostol 0.4 mg, if not childbirth, every 3 h administration misoprostol 0.4 mg, not repeated more than 4 times.The effective rate, duration of labor induction, blood loss, period of vagina hemorrhage and dosage of misoprostol were com-pared between the two groups.Results The total effective rate were 93.54%and 100.00%for the control and experiment group respectively without statistical difference ( P>0.05 ) .The duration of labor induc-tion, blood loss, dosage of misoprostol in experiment group were statisti-cally lower than those in control group ( P <0.05 ) .Thirteen cases of nausea and vomiting, 2 cases of fever and 1 case of rash was observed in experiment group, and 12 cases of nausea and vomiting, 1 case of fever was found in control group.The incidences of adverse drug reactions had no statistical difference between the two groups ( P >0.05 ) .Conclusion Mifepristone combined with misoprostol were effective and safe for termination of pregnancy, and misoprostol through intravaginally administration had better efficacy.
