中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
The Chinese Journal of Clinical Pharmacology
2015年
22期
2236-2239
,共4页
国产头孢雷特%体外%抗菌活性
國產頭孢雷特%體外%抗菌活性
국산두포뢰특%체외%항균활성
ceforanide%in vitro%antimicrobial activity
目的 评价国产头孢雷特体外抗菌活性. 方法 用琼脂二倍稀释法,测定国产头孢雷特对617株临床分离致病菌的最低抑菌浓度(MIC). 结果 国产头孢雷特对临床分离甲氧西林敏感性金黄色葡萄球菌、β溶血性链球菌、超广谱β内酰胺酶阴性( ESBLs-)大肠埃希菌、ESBL-肺炎克雷伯菌、变形杆菌属、伤寒沙门菌、流感嗜血杆菌、卡他莫拉菌有较强抗菌作用,MIC90值在0.25~8 mg·L-1.结论 国产头孢雷特体外抗菌活性,抗菌谱与头孢呋辛、头孢孟多酯、头孢替安相似,对大多数革兰氏阴性菌的抗菌效力较强;其耐药率与对照相当.
目的 評價國產頭孢雷特體外抗菌活性. 方法 用瓊脂二倍稀釋法,測定國產頭孢雷特對617株臨床分離緻病菌的最低抑菌濃度(MIC). 結果 國產頭孢雷特對臨床分離甲氧西林敏感性金黃色葡萄毬菌、β溶血性鏈毬菌、超廣譜β內酰胺酶陰性( ESBLs-)大腸埃希菌、ESBL-肺炎剋雷伯菌、變形桿菌屬、傷寒沙門菌、流感嗜血桿菌、卡他莫拉菌有較彊抗菌作用,MIC90值在0.25~8 mg·L-1.結論 國產頭孢雷特體外抗菌活性,抗菌譜與頭孢呋辛、頭孢孟多酯、頭孢替安相似,對大多數革蘭氏陰性菌的抗菌效力較彊;其耐藥率與對照相噹.
목적 평개국산두포뢰특체외항균활성. 방법 용경지이배희석법,측정국산두포뢰특대617주림상분리치병균적최저억균농도(MIC). 결과 국산두포뢰특대림상분리갑양서림민감성금황색포도구균、β용혈성련구균、초엄보β내선알매음성( ESBLs-)대장애희균、ESBL-폐염극뢰백균、변형간균속、상한사문균、류감기혈간균、잡타막랍균유교강항균작용,MIC90치재0.25~8 mg·L-1.결론 국산두포뢰특체외항균활성,항균보여두포부신、두포맹다지、두포체안상사,대대다수혁란씨음성균적항균효력교강;기내약솔여대조상당.
Objective To evaluate the in vitro antimicrobial activity of ceforanide against clinical isolates.Methods A total of 617 strains were included in this study.Minimal inhibitory concentrations ( MIC) of anti-microbials were performed by the agar dilution method. Results Ceforanide had a good antibacterial activity against methicillin-senstive Staphylococcus aureus( MSSA) ,βStreptococeus haemolyticus, Escherichia coli nagative extended -spectrum βlactamases ( ESBLs-) , Klebsiella pneumoniae ESBLs-, Proteus spp, Salmonella typhi, Haemophilus Influ-enzae, Moraxella catarrhalis.The MIC90 of ceforanide against above bac-teria were 0.25-8 mg·L-1 .Conclusion Ceforanide exhibits a good activity against most clinical strains in this study.The antibacterial activi-ty of ceforanide were similar with cefuroxime, cefamandole, cefotiam.
