中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
The Chinese Journal of Clinical Pharmacology
2015年
22期
2226-2228
,共3页
舒芬太尼%氯诺昔康%术后自控镇痛%口腔颌面部手术%不良反应
舒芬太尼%氯諾昔康%術後自控鎮痛%口腔頜麵部手術%不良反應
서분태니%록낙석강%술후자공진통%구강합면부수술%불량반응
sulfentanyl%lornoxicam%patient controlled intravenous analgesia%oral and maxillofacial operation%adverse drug reaction
目的 评价氯诺昔康与舒芬太尼用于口腔颌面外科手术后静脉自控镇痛的临床疗效及安全性. 方法 将58例择期进行口腔颌面外科手术患者随机分为试验组28例和对照组30例. 试验组予以氯诺昔康32 mg+格拉司琼3 mg+0.9%氯化钠至100 mL,接镇痛泵静脉自控镇痛;对照组予以1 mg·kg-1舒芬太尼+格拉司琼3 mg+0.9%氯化钠至100 mL,接镇痛泵静脉自控镇痛. 比较2组患者术后4,8,12,24和48h镇痛评分及镇静评分、满意度和不良反应发生率.结果 2组患者术后各时点镇痛评分及镇静评分差异无统计学意义( P>0.05). 2组患者术后镇痛满意度比较差异无统计学意义(P>0.05). 试验组的恶心呕吐及头晕等不良反应发生率为3.6%显著低于对照组23.3%(P<0.05). 结论 氯诺昔康用于口腔颌面外科手术后自控镇痛效果与舒芬太尼相当,但不良反应发生率显著低于舒芬太尼.
目的 評價氯諾昔康與舒芬太尼用于口腔頜麵外科手術後靜脈自控鎮痛的臨床療效及安全性. 方法 將58例擇期進行口腔頜麵外科手術患者隨機分為試驗組28例和對照組30例. 試驗組予以氯諾昔康32 mg+格拉司瓊3 mg+0.9%氯化鈉至100 mL,接鎮痛泵靜脈自控鎮痛;對照組予以1 mg·kg-1舒芬太尼+格拉司瓊3 mg+0.9%氯化鈉至100 mL,接鎮痛泵靜脈自控鎮痛. 比較2組患者術後4,8,12,24和48h鎮痛評分及鎮靜評分、滿意度和不良反應髮生率.結果 2組患者術後各時點鎮痛評分及鎮靜評分差異無統計學意義( P>0.05). 2組患者術後鎮痛滿意度比較差異無統計學意義(P>0.05). 試驗組的噁心嘔吐及頭暈等不良反應髮生率為3.6%顯著低于對照組23.3%(P<0.05). 結論 氯諾昔康用于口腔頜麵外科手術後自控鎮痛效果與舒芬太尼相噹,但不良反應髮生率顯著低于舒芬太尼.
목적 평개록낙석강여서분태니용우구강합면외과수술후정맥자공진통적림상료효급안전성. 방법 장58례택기진행구강합면외과수술환자수궤분위시험조28례화대조조30례. 시험조여이록낙석강32 mg+격랍사경3 mg+0.9%록화납지100 mL,접진통빙정맥자공진통;대조조여이1 mg·kg-1서분태니+격랍사경3 mg+0.9%록화납지100 mL,접진통빙정맥자공진통. 비교2조환자술후4,8,12,24화48h진통평분급진정평분、만의도화불량반응발생솔.결과 2조환자술후각시점진통평분급진정평분차이무통계학의의( P>0.05). 2조환자술후진통만의도비교차이무통계학의의(P>0.05). 시험조적악심구토급두훈등불량반응발생솔위3.6%현저저우대조조23.3%(P<0.05). 결론 록낙석강용우구강합면외과수술후자공진통효과여서분태니상당,단불량반응발생솔현저저우서분태니.
Objective To evaluate the clinical efficacy and safety of lor-noxicam or sulfentanyl on patient controlled intravenous analgesia ( PCIA ) in postoperative patients with oral and maxillofacial operation ( OMS).Methods Fifty-eight patients with oral and maxillofacial op-eration were randomly divided into treatment group ( n=28 ) and control group ( n=30 ) .Patients in the treatment group were given lornoxicam 32 mg+granisetron 3 mg+0.9% NaCl up to 100 mL PCIA.And pa-tients in the control group were administrated of sulfentanyl 1 mg·kg -1+granisetron 3 mg+0.9% NaCl up to 100 mL PCIA.After operation 4, 8, 12, 24 and 48 h, the pain control satisfaction and PCIA related adverse drug reactions such as nausea and vomiting and dizzy were evalu-ated between the two groups.Results The pain control, sedation effects and pain relief satisfaction had no statistical difference between the two groups in the above time points ( P>0.05 ) .The PCIA related nausea and vomit or dizzy in treatment group was 3.6% which was significant lower than that in control group 23.3%(P<0.05).Conclusion Com-pared with sulfentanyl, Lornoxicam had the same pain control and seda-tion effects for PCIA in patients with oral and maxillofacial operation, but with less nausea and vomiting or dizzy adverse drug reactions.
