中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
The Chinese Journal of Clinical Pharmacology
2015年
22期
2190-2192
,共3页
米力农%地高辛%慢性阻塞性肺疾病%肺源性心脏病%心力衰竭
米力農%地高辛%慢性阻塞性肺疾病%肺源性心髒病%心力衰竭
미력농%지고신%만성조새성폐질병%폐원성심장병%심력쇠갈
milrinone%digoxin%chronic obstructive pulmonary disease%pulmonary heart disease%heart failure
目的 评价米力农联合低剂量地高辛治疗慢性肺源性心脏病,控制心力衰竭的临床疗效和安全性. 方法 将60例慢性肺源性心脏病合并心力衰竭患者随机分为对照组30例和试验组30例. 对照组予以地高辛0.125 mg·d-1 ,每日1次;试验组在对照组的基础上,予以米力农注射液2 mg+0.9%氯化钠20 mL静脉推注,随后静脉滴注米力农注射液13 mg+0.9%氯化钠250 mL,2组疗程均为2周. 观察2组患者的临床疗效、心率、肺动脉压变化及不良反应发生率.结果 在改善心功能方面,对照组和试验组的总有效率分别为73.33%和93.33%(P<0.05). 治疗后,2组患者血氧分压较治疗前显著升高(P<0.05),心率、二氧化碳分压和肺动脉压较治疗前显著降低( P<0.05 ) ,且试验组上述指标变化明显优于对照组( P<0.05 ). 2组患者不良反应发生率比较差异无统计学意义( P>0.05). 结论 米力农联合地高辛治疗慢性肺源性心脏病合并心力衰竭的临床疗效确切,且不增加不良反应的发生率.
目的 評價米力農聯閤低劑量地高辛治療慢性肺源性心髒病,控製心力衰竭的臨床療效和安全性. 方法 將60例慢性肺源性心髒病閤併心力衰竭患者隨機分為對照組30例和試驗組30例. 對照組予以地高辛0.125 mg·d-1 ,每日1次;試驗組在對照組的基礎上,予以米力農註射液2 mg+0.9%氯化鈉20 mL靜脈推註,隨後靜脈滴註米力農註射液13 mg+0.9%氯化鈉250 mL,2組療程均為2週. 觀察2組患者的臨床療效、心率、肺動脈壓變化及不良反應髮生率.結果 在改善心功能方麵,對照組和試驗組的總有效率分彆為73.33%和93.33%(P<0.05). 治療後,2組患者血氧分壓較治療前顯著升高(P<0.05),心率、二氧化碳分壓和肺動脈壓較治療前顯著降低( P<0.05 ) ,且試驗組上述指標變化明顯優于對照組( P<0.05 ). 2組患者不良反應髮生率比較差異無統計學意義( P>0.05). 結論 米力農聯閤地高辛治療慢性肺源性心髒病閤併心力衰竭的臨床療效確切,且不增加不良反應的髮生率.
목적 평개미력농연합저제량지고신치료만성폐원성심장병,공제심력쇠갈적림상료효화안전성. 방법 장60례만성폐원성심장병합병심력쇠갈환자수궤분위대조조30례화시험조30례. 대조조여이지고신0.125 mg·d-1 ,매일1차;시험조재대조조적기출상,여이미력농주사액2 mg+0.9%록화납20 mL정맥추주,수후정맥적주미력농주사액13 mg+0.9%록화납250 mL,2조료정균위2주. 관찰2조환자적림상료효、심솔、폐동맥압변화급불량반응발생솔.결과 재개선심공능방면,대조조화시험조적총유효솔분별위73.33%화93.33%(P<0.05). 치료후,2조환자혈양분압교치료전현저승고(P<0.05),심솔、이양화탄분압화폐동맥압교치료전현저강저( P<0.05 ) ,차시험조상술지표변화명현우우대조조( P<0.05 ). 2조환자불량반응발생솔비교차이무통계학의의( P>0.05). 결론 미력농연합지고신치료만성폐원성심장병합병심력쇠갈적림상료효학절,차불증가불량반응적발생솔.
Objective To explore the clinical efficacy and safety of milrinone combined with low-dose digoxin for treatment of chronic pul-monary heart disease.Methods A total of 60 patients suffering from chronic cor pulmonale disease ( COPD ) with heart failure were rando-mized into two groups.The control group( n=30) was treated with low-dose digoxin to control heart failure.The treatment group ( n=30 ) was treated with milrinone plus low -dose digoxin to control heart failure. Other treatments were similar.Results In improvement of cardiac func-tion, the total efficiencies of control group and treatment group were 73.33%and 93.33%, respectively, there was a marked difference be-tween the two groups (P<0.05).After treatment, the alveolar oxygen partial pressure(PaO2)of two groups increased significantly (P<0.05), while the heart rate, alveolar partial pressure of carbon dioxide ( PaCO2 ) and pulmonary artery pressure decreased significantly(P<0.05)had sta-tistical significance between two groups ( P<0.01) , the above indicators of treatment group were better than those of control group. Conclusion The regimen of milrinone plus low-dose digoxin is effec-tive in controlling heart failure of patients with chronic cor pulmonale. Hence, it is worthy of being recommended in clinical practice.
