中国肿瘤临床
中國腫瘤臨床
중국종류림상
Chinese Journal of Clinical Oncology
2015年
22期
1096-1099
,共4页
孙艳丽%刘颖%付大军%程世凯%刘颖%朱星华%罗福永%黄康%张锦华
孫豔麗%劉穎%付大軍%程世凱%劉穎%硃星華%囉福永%黃康%張錦華
손염려%류영%부대군%정세개%류영%주성화%라복영%황강%장금화
新生儿%神经母细胞瘤%临床特点%治疗%预后
新生兒%神經母細胞瘤%臨床特點%治療%預後
신생인%신경모세포류%림상특점%치료%예후
neonate%neuroblastoma%clinical feature%treatment%prognosis
目的:提高对新生儿神经母细胞瘤临床特征及预后的认识.方法:对2010年7月至2015年3月中国医科大学附属第四医院儿科收治的8例新生儿神经母细胞瘤患儿的临床表现、组织病理分型、治疗及预后进行回顾性分析.结果:患儿中男性5例,女性3例,发病年龄孕24周至生后28天,中位数年龄9天.原发肿瘤4例位于左肾上腺,2例位于右肾上腺,1例位于双肾上腺,1例位于盆腔.6例经肿瘤组织病理学确诊,2例经骨髓细胞学确诊.临床分期:1期1例,2期1例,4S期6例.5例给予原发肿瘤切除和术后化疗,1例给予一侧原发肿瘤切除和术后化疗,2例仅给予化疗.8例均生存,随访时间6~56个月,6例均达持续完全缓解,2例带瘤生存.结论:新生儿神经母细胞瘤具有自身生物学特性,临床分期主要为1期、2期和4S期,病理分型多数是神经母细胞瘤,预后良好.
目的:提高對新生兒神經母細胞瘤臨床特徵及預後的認識.方法:對2010年7月至2015年3月中國醫科大學附屬第四醫院兒科收治的8例新生兒神經母細胞瘤患兒的臨床錶現、組織病理分型、治療及預後進行迴顧性分析.結果:患兒中男性5例,女性3例,髮病年齡孕24週至生後28天,中位數年齡9天.原髮腫瘤4例位于左腎上腺,2例位于右腎上腺,1例位于雙腎上腺,1例位于盆腔.6例經腫瘤組織病理學確診,2例經骨髓細胞學確診.臨床分期:1期1例,2期1例,4S期6例.5例給予原髮腫瘤切除和術後化療,1例給予一側原髮腫瘤切除和術後化療,2例僅給予化療.8例均生存,隨訪時間6~56箇月,6例均達持續完全緩解,2例帶瘤生存.結論:新生兒神經母細胞瘤具有自身生物學特性,臨床分期主要為1期、2期和4S期,病理分型多數是神經母細胞瘤,預後良好.
목적:제고대신생인신경모세포류림상특정급예후적인식.방법:대2010년7월지2015년3월중국의과대학부속제사의원인과수치적8례신생인신경모세포류환인적림상표현、조직병리분형、치료급예후진행회고성분석.결과:환인중남성5례,녀성3례,발병년령잉24주지생후28천,중위수년령9천.원발종류4례위우좌신상선,2례위우우신상선,1례위우쌍신상선,1례위우분강.6례경종류조직병이학학진,2례경골수세포학학진.림상분기:1기1례,2기1례,4S기6례.5례급여원발종류절제화술후화료,1례급여일측원발종류절제화술후화료,2례부급여화료.8례균생존,수방시간6~56개월,6례균체지속완전완해,2례대류생존.결론:신생인신경모세포류구유자신생물학특성,림상분기주요위1기、2기화4S기,병리분형다수시신경모세포류,예후량호.
Objective:To investigate the clinical features and prognosis of neuroblastoma in neonates. Methods:Clinical data of eight patients with neonatal neuroblastoma who were admitted to the Fourth Affiliated Hospital of China Medical University between July 2010 and March 2015 were retrospectively analyzed. Results:The patients included five males and three females with a median age of 9 days. The primary site of the tumors was as follows:left adrenal gland in four cases, right adrenal gland in two cases, bilateral adrenal glands in one case, and pelvic cavity in one case. Six of the eight patients were finally diagnosed via tumor histopathology, and the other two patients were diagnosed by bone marrow cytology. The clinical staging results were obtained as follows:stage 1 in one of the eight patients, stage 2 in another patient, and stage 4S in the remaining six patients. Primary tumor resection and postoperative che-motherapy were conducted in five patients. Unilateral resection of the primary tumor and postoperative chemotherapy were performed in one of the patients, and a simple chemotherapy of the tumor was conducted in the other two patients. All eight patients survived, with a follow-up of 6 to 56 months. Continued complete remission was achieved by six patients, and survival with tumor was achieved in the other two patients. Conclusion: Neonatal neuroblastoma has its own biological characteristics. The main clinical stages of the tumor are stage 1, 2, and 4S. The majority of pathological typing is neuroblastoma, and the prognosis is favorable.