CAJ | 학술논문

为了解血管紧张素转换酶（ACE）基因I／D多态性与中国人群缺血性脑卒中之间的关系，利用PCR和分子杂交技术对北京地区294例缺血性脑卒中患者及280例非卒中者的ACE基因I／D多态性进行了检测和分析。结果表明，I／D多态性在两组人群中的分布均符合Hardy-Weinberg遗传平衡定律，但该位点基因型频率及等位基因频率在两组人群中分布无差异，与英国人群相比则有显著差异。提示ACE基因I／D多态性不是中国人群缺血性脑卒中发病的遗传学危险因素。
위료해혈관긴장소전환매（ACE）기인I／D다태성여중국인군결혈성뇌졸중지간적관계，이용PCR화분자잡교기술대북경지구294례결혈성뇌졸중환자급280례비졸중자적ACE기인I／D다태성진행료검측화분석。결과표명，I／D다태성재량조인군중적분포균부합Hardy-Weinberg유전평형정률，단해위점기인형빈솔급등위기인빈솔재량조인군중분포무차이，여영국인군상비칙유현저차이。제시ACE기인I／D다태성불시중국인군결혈성뇌졸중발병적유전학위험인소。
To evaluate the relationship between angiotensin converting enzyme（ACE） gene I／D polymorphism and ischemic stroke in Chinese population，the I／D genotype of 294 patients with ischemic stroke and 280 controls without stroke was determined by polymerase chain reaction（PCR）and corresponding probe hybridization.Results showed that the I／D polymorphism was in agreement with Hardy-Weinberg equilibrium in either cases or controls，but neither the prevalence rates of genotypes nor allele frequency of I／D polymorphism was significantly different between these two groups.In addition，the distribution of this variant in China is very distinct to that of England.This suggests that the I／D polymorphism of ACE gene cannot be a genetic risk of ischemic stroke in Chinese population.