CAJ | 학술논문

用直流伏安法(DCV)，微分脉冲伏安法(DPV)和循环伏安法(CV)在玻碳电极(GCE)上研究了双嘧达莫(DPM)在不同介质中的阳极伏安行为，发现在0.01mol/LHCl溶液中于0.62V(vs.Ag/AgCl)右左产生一个阳极氧化峰，其峰高与浓度的线性方程分别为y=0.0004+0.17C(0.05～1．0mg/L)和y=0.052+0.22C(0.5～10mg/L)，在此体系中大多数金属离子和20多种有机生化物质不干扰测定。采用该方法可不经分离，直接测定药物制剂和尿样中DPM的含量。同时对DPM的电极反应机理进行了探讨。
용직류복안법(DCV)，미분맥충복안법(DPV)화순배복안법(CV)재파탄전겁(GCE)상연구료쌍밀체막(DPM)재불동개질중적양겁복안행위，발현재0.01mol/LHCl용액중우0.62V(vs.Ag/AgCl)우좌산생일개양겁양화봉，기봉고여농도적선성방정분별위y=0.0004+0.17C(0.05～1．0mg/L)화y=0.052+0.22C(0.5～10mg/L)，재차체계중대다수금속리자화20다충유궤생화물질불간우측정。채용해방법가불경분리，직접측정약물제제화뇨양중DPM적함량。동시대DPM적전겁반응궤리진행료탐토。
The anodic voltammetric behavior of dipyridamole (DPM) in t hepresence of various electrolytes was studetd by direct-current voltammetry, di fferential-pulse voltammetry and cyclic voltammetry at a glassy carbon electrod e. In a medium of 0.01 mol/L HCl, an oxidative peak of dipyridamole was obtained . The peak potential is at about 0.62 V(vs.Ag/AgCl). The peak current is lin early increased with the concentration of dipyridamole over the range of 0.05～ 10 mg/L. The method has been used for the direct determination of dipyrida mole in tablets. The recoveries of dipyridamole in urine samples are 89%. Experi mental results proved that the electrode reaction was diffustion controlled and irreversible.