CAJ | 학술논문

本文采用RT-PCR技术对25例习惯性流产胚胎绒毛细胞和25例正常妊娠的人工流产绒毛细胞LIF基因表达进行了研究，以探讨胚胎绒毛组织LIF基因表达与流产之病因的关系。结果发现在流产组中，有5例（占20%）流产胚胎绒毛组织无LIF基因表达，而正常组绒毛组织中均检测到LIF基因表达，两组经统计学处理具有显著性差异（P＜0.01）。本研究结果提示胚胎绒毛组织LIF基因表达缺陷可能是造成流产的原因之一。
본문채용RT-PCR기술대25례습관성유산배태융모세포화25례정상임신적인공유산융모세포LIF기인표체진행료연구，이탐토배태융모조직LIF기인표체여유산지병인적관계。결과발현재유산조중，유5례（점20%）유산배태융모조직무LIF기인표체，이정상조융모조직중균검측도LIF기인표체，량조경통계학처리구유현저성차이（P＜0.01）。본연구결과제시배태융모조직LIF기인표체결함가능시조성유산적원인지일。
In order to find out relationship between expression of leukemia inhibitory factor(LIF) of chorionic tissue and habitual abortion, expression of LIF of chorionic tissues from 25 cases habitual abortions and normal controls was analysized by reverse transcription-polymerase chain reaction method. The result showed there was no expression of LIF in 5 chorion tissue samplings from habitual abortion(20%). There is a significant difference btween the two groups(P＜0.01).The findings suggest that cause of habitual abortion might be related to no-expression of LIF gene.