中外健康文摘
中外健康文摘
중외건강문적
WORLD HEALTH DIGEST
2009年
18期
88-90
,共3页
利培酮%精神分裂症%血浆药物浓度%性别差异
利培酮%精神分裂癥%血漿藥物濃度%性彆差異
리배동%정신분렬증%혈장약물농도%성별차이
Risperidone Schizophrenic Blood concentration Gender differences
目的 探索利培酮对精神分裂症血浆药物浓度的性别差异.方法 对49例符合DSM-IV诊断标准的精神分裂症患者,按性别分为两组,定期进行血药浓度检测. 结果 用相同剂量的利培酮(各2mg/d)对男、女两组治疗,2周后检测血药浓度有非常显 著统计学意义P <0.05;经剂量调整(男3mg 女3.5mg),6周后再次对利培酮血药浓度检测,两组的血药浓度无显著统计学意义, P>0.05.结论 用相同剂量利培酮治疗精神分裂症,两组血药浓度检测有显著统计学意义,提示用相同剂量利培酮治疗精神分裂症时,有性别差异.
目的 探索利培酮對精神分裂癥血漿藥物濃度的性彆差異.方法 對49例符閤DSM-IV診斷標準的精神分裂癥患者,按性彆分為兩組,定期進行血藥濃度檢測. 結果 用相同劑量的利培酮(各2mg/d)對男、女兩組治療,2週後檢測血藥濃度有非常顯 著統計學意義P <0.05;經劑量調整(男3mg 女3.5mg),6週後再次對利培酮血藥濃度檢測,兩組的血藥濃度無顯著統計學意義, P>0.05.結論 用相同劑量利培酮治療精神分裂癥,兩組血藥濃度檢測有顯著統計學意義,提示用相同劑量利培酮治療精神分裂癥時,有性彆差異.
목적 탐색리배동대정신분렬증혈장약물농도적성별차이.방법 대49례부합DSM-IV진단표준적정신분렬증환자,안성별분위량조,정기진행혈약농도검측. 결과 용상동제량적리배동(각2mg/d)대남、녀량조치료,2주후검측혈약농도유비상현 저통계학의의P <0.05;경제량조정(남3mg 녀3.5mg),6주후재차대리배동혈약농도검측,량조적혈약농도무현저통계학의의, P>0.05.결론 용상동제량리배동치료정신분렬증,량조혈약농도검측유현저통계학의의,제시용상동제량리배동치료정신분렬증시,유성별차이.
objective:The purpose is to explore for risperidone in schizophrenic patients blood concentration and efficacy of the gender gab.Methods:A total of 49 patients met with the criteria of DMS-IV for Schizophreria were assigned to Male and Female team, After two weeks and six weeks dose adjustments again risperidone plasma concertration detection and analysis of effects. Results: The same dose of risperidone for the treatment of two groups of men and women, two weeks after the detection of blood concentration,there are significant differences; P<0.05 Efficacy of the drug was no singificant statistical significance P>0.05, but there are obvious clinical significance.After 6 weeks after dose adjustments again risperidone plasma concertration detection and analysis of the effects,both P>0.05, there was no significant statistical significance. Conclusion: Risperidone for the treatment of patients with schizophrenia are gender differences.
