CAJ | 학술논문

目的：研究维拉帕米对硫唑嘌呤代谢物6-巯嘌呤药动学的影响。方法：采用高效液相色谱法(HPLC)，以8只健康家兔为实验对象，对硫唑嘌呤单用及与维拉帕米合用后血中硫唑嘌呤代谢物6-巯嘌呤浓度(6-MP)及药动学参数的变化进行观察。结果：合用维拉帕米后，6-MP的表观分布容积(Vd)增加3倍，AUC降低65.8％，清除率（Cls)增加3倍，t1/2β延长1.5倍，其它药动学参数无显著影响。结论：维拉帕米使硫唑嘌呤代谢物6-巯嘌呤的血药浓度明显降低及清除率明显增加。
목적：연구유랍파미대류서표령대사물6-구표령약동학적영향。방법：채용고효액상색보법(HPLC)，이8지건강가토위실험대상，대류서표령단용급여유랍파미합용후혈중류서표령대사물6-구표령농도(6-MP)급약동학삼수적변화진행관찰。결과：합용유랍파미후，6-MP적표관분포용적(Vd)증가3배，AUC강저65.8％，청제솔（Cls)증가3배，t1/2β연장1.5배，기타약동학삼수무현저영향。결론：유랍파미사류서표령대사물6-구표령적혈약농도명현강저급청제솔명현증가。
OBJECTIVE:To study effects of verapamil on 6-mercaptopurine pharmacokinetics. METHODS:Serum concentration of 6-mercaptopurine (6-MP) , a active metobilite of azathiopurine (Azp) , was determined by HPLC，and the pharmacokinetic parameters were researched after single administration of Azp and co-administration verapamil(Vp) in 8 rabbits.RESULTS:The results indicated that Vd and Cls of 6-MP increased 3 times , T1/2β raised 1.5 times , AUC decreased 65.8 percent , and other pharmacokinetic parameters have no significant differences after co-administration Vp in 8 rabbits.CONCLUSION:6-MP serum concentration was decreased and clearance rate increased evidently after co-administration verapamil in rabbits.