CAJ | 학술논문

目的:探讨利塞膦酸钠对血脂和骨量的影响及血脂与骨密度之间的关系.方法:116例绝经后骨质疏松患者随机分为两组,治疗组57例,服用利塞膦酸钠5 mg,每日1次,对照组59例,服用安慰剂,方法同上.两组均服凯思立D每日1片,睡前服用.两组患者均连续服药12个月,比较两组治疗前后骨密度及血脂的变化.结果:两组患者经治疗12个月后,腰椎L2-4骨密度及总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)差异有显著性(P<0.05),治疗组腰椎L2-4骨密度较对照组高,治疗组TC、LDL-C较对照组低;两组Ward三角、股骨近端总骨矿物质密度(BMD)及血甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)差异无显著性(P>0.05).两组腰椎L2-4骨密度及TC、LDL-C差值差异有显著性,治疗组腰椎L2-4骨密度上升值高于对照组,TC及LDL-C下降值均高于对照组;股骨近端总BMD、Ward三角BMD及TG、HDL-C两组治疗前后差值间差异无显著性(P>0.05).结论:骨质疏松患者经过利塞膦酸钠治疗,腰椎L2-4骨密度显著提高,血脂显著降低,血脂与骨密度之间可能存在一定的关系.
목적:탐토리새련산납대혈지화골량적영향급혈지여골밀도지간적관계.방법:116례절경후골질소송환자수궤분위량조,치료조57례,복용리새련산납5 mg,매일1차,대조조59례,복용안위제,방법동상.량조균복개사립D매일1편,수전복용.량조환자균련속복약12개월,비교량조치료전후골밀도급혈지적변화.결과:량조환자경치료12개월후,요추L2-4골밀도급총담고순(TC)、저밀도지단백담고순(LDL-C)차이유현저성(P<0.05),치료조요추L2-4골밀도교대조조고,치료조TC、LDL-C교대조조저;량조Ward삼각、고골근단총골광물질밀도(BMD)급혈감유삼지(TG)、고밀도지단백담고순(HDL-C)차이무현저성(P>0.05).량조요추L2-4골밀도급TC、LDL-C차치차이유현저성,치료조요추L2-4골밀도상승치고우대조조,TC급LDL-C하강치균고우대조조;고골근단총BMD、Ward삼각BMD급TG、HDL-C량조치료전후차치간차이무현저성(P>0.05).결론:골질소송환자경과리새련산납치료,요추L2-4골밀도현저제고,혈지현저강저,혈지여골밀도지간가능존재일정적관계.
Objective:To study the effect of risedronate sodium on blood lipid and bone mineral density (BMD)and the relationship between blood lipid and BMD.Methods:116 postmenopansal osteoporosis patients were randomly divided into two groups.Group A (treatment group) were treated by risedronate sodium (5mg),once daily and group B (control group) received placebo.Both groups took Calcichew D,one tablet daily before sleeping.The treatment lasted 12 months.The changes of bone density and blood lipid were compared before and after treatment in two groups.Results:The bone density in L2-4 and total cholesterol (TC),HDL-C had significant difference after 12-month treatment between the two groups (P<0.05).The bone density in L2-4 of the treatment group was higher than that of the control group,whil TC ,LDL-C were lower than those of the control group,the total BMD in Ward triangle and proximal femur,TG,HDL-C had no significant difference (P>0.05).The BMD increment in L2-4 of the treatment group was higher than that of the control group.The decrease value of TC,LDL-C was higher than that of the control group.There was no significant difference in the total BMD in Ward triangle and proximal femur,TG and HDL-C before and after treatment between the two groups (P>0.05).Conclusion:After risedronate sodium treatment, BMD of lumbar vertebrae in the osteoporosis patients obviously increases and blood lipid markedly decreases.Blood lipid may be related with BMD.