CAJ | 학술논문

目的观察脓毒症患者早期血浆Apelin水平的变化规律,探讨其对发生脓毒症性休克的预测价值.方法采用酶联免疫分析法测定48例脓毒症患者血浆Apelin水平,并进行APACHEⅡ评分,分别于脓毒症、严重脓毒症和脓毒症性休克后第1天检测血浆Apelin水平;另择20例健康志愿者作为对照组,比较各组血浆Apelin水平.结果与对照组相比,脓毒症组、严重脓毒症组、脓毒症性休克组血浆Apelin水平明显升高(P均＜0.01);且脓毒症性休克组明显高于脓毒症组和重度脓毒症组.脓毒症组、严重脓毒症组、脓毒症性休克组的APACHEⅡ评分呈逐渐升高趋势.相关性分析显示,脓毒症患者早期血浆Apelin水平与APACHEⅡ评分无明显相关性.结论脓毒症患者早期即出现血浆Apelin水平变化,其水平反映脓毒症患者病情严重程度,血浆Apelin水平可作为预测脓毒症性休克发生的指标.
목적 관찰농독증환자조기혈장Apelin수평적변화규률,탐토기대발생농독증성휴극적예측개치.방법 채용매련면역분석법측정48례농독증환자혈장Apelin수평,병진행APACHEⅡ평분,분별우농독증、엄중농독증화농독증성휴극후제1천검측혈장Apelin수평;령택20례건강지원자작위대조조,비교각조혈장Apelin수평.결과 여대조조상비,농독증조、엄중농독증조、농독증성휴극조혈장Apelin수평명현승고(P균＜0.01);차농독증성휴극조명현고우농독증조화중도농독증조.농독증조、엄중농독증조、농독증성휴극조적APACHEⅡ평분정축점승고추세.상관성분석현시,농독증환자조기혈장Apelin수평여APACHEⅡ평분무명현상관성.결론 농독증환자조기즉출현혈장Apelin수평변화,기수평반영농독증환자병정엄중정도,혈장Apelin수평가작위예측농독증성휴극발생적지표.
Objective To observe the levels of serum Apelin in patients with sepsis .Methods A prospective and observational study was underwent in patients with sepsis who admitted to intensive care unit(ICU). Blood samples were collected daily and APACHEⅡscores were calculated daily. The concentration of serum Apelin was measured by enzyme-linked immunosorbent assay(ELISA). According to the data of serum Apelin measured at every stage,48 patients were divided into three groups:sepsis group, severe sepsis group and septic shock group, and 20 healthy controlled people were detected and compared. Results The levels of serum Apelin in sepsis group, severe sepsis group and septic shock group were significantly higher than those in control group,the difference was significant(P＜0.01). The level of serum Apelin was significantly higher in septic shock group when compared with sepsis group and severe sepsis group,the difference was significant(P＜0.05). The severity of patients rose gradually when the levels of serum Apelin increased. The levels of serum Apelin did not contribute to APACHEⅡscores. Conclusions The level of serum Apelin in patients changs with sepsis serious degree, Which may provide a clue of diagnosing sepsis.