华西药学杂志
華西藥學雜誌
화서약학잡지
WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
2000年
5期
349-351
,共3页
六氢苯并[a]喹嗪-4-酮%合成%钙拮抗活性%放射性核素45Ca
六氫苯併[a]喹嗪-4-酮%閤成%鈣拮抗活性%放射性覈素45Ca
륙경분병[a]규진-4-동%합성%개길항활성%방사성핵소45Ca
Hexahydrobenzo［a］quinolizin-4-one%Synthesis%Ca2+ antagonizing activity%Radionuclide 45 Ca
目的:设计并合成了一系列六氢苯并［a］喹嗪-4-酮类化合物，对其钙拮抗活性作初步研究；方法:用45 Ca跨膜内流动测定方法研究了目标物对大鼠主动脉电压依赖性钙离子通道（PDC）Ca2+内流的影响；结果:四个化合物对PDC均有显著阻滞作用；结论:初步药理实验显示，四个化合物具有一定的钙拮抗活性。
目的:設計併閤成瞭一繫列六氫苯併［a］喹嗪-4-酮類化閤物，對其鈣拮抗活性作初步研究；方法:用45 Ca跨膜內流動測定方法研究瞭目標物對大鼠主動脈電壓依賴性鈣離子通道（PDC）Ca2+內流的影響；結果:四箇化閤物對PDC均有顯著阻滯作用；結論:初步藥理實驗顯示，四箇化閤物具有一定的鈣拮抗活性。
목적:설계병합성료일계렬륙경분병［a］규진-4-동류화합물，대기개길항활성작초보연구；방법:용45 Ca과막내류동측정방법연구료목표물대대서주동맥전압의뢰성개리자통도（PDC）Ca2+내류적영향；결과:사개화합물대PDC균유현저조체작용；결론:초보약리실험현시，사개화합물구유일정적개길항활성。
A series of derivatives of hexahydrobenzo［a］quinolizin-4-one have been designed and synthesized. Four of them have been determined on their inhabitive effect on potential-dependent Ca2+channels(PDC).METHODS: The four compounds have been studied on Ca2+ antagonistic effect in rat aorta by using 45 Ca transmembrane influx technique.RESULTS:The four compounds appeared strongly inhabitive effect on PDC.CONCLUSION:Preliminary results showed that all of the four compounds possessed Ca2+ antagonizing activity.
