CAJ | 학술논문

目的：观察生脉注射液对阻塞性黄疸（阻黄）术后炎症介质及肾功能的作用。方法：阻黄及非黄疸的肝胆外科患者分成三组，术后给予一般治疗阻黄（OJ）组、非黄疸（NON-OJ）组及生脉注射液治疗阻黄组。动态观察血浆炎症介质内毒素（LPs）、肿瘤坏死因子（TNF-α）、白细胞介素-6，8（IL-6，IL-8）、内皮素（ET）以及肾脏功能指标尿转铁蛋白（TFR）、尿白蛋白（ALB）及尿视黄醇（RBP）的变化。结果：生脉注射液治疗组术后7天与术后1天相比，LPs、IL-6、IL-8、ET、TNF-α、TFR、RBP、ALB明显下降（P<0.05〉，且低于或接近术前水平，黄疸对照组在术后7天与术后1天相比无显著差异（P>0.05）。结论：生脉注射液对阻黄患者术后LPs有拮抗作用，同时降低其它炎症介质水平，另外还具有保护肾脏功能的作用。
목적：관찰생맥주사액대조새성황달（조황）술후염증개질급신공능적작용。방법：조황급비황달적간담외과환자분성삼조，술후급여일반치료조황（OJ）조、비황달（NON-OJ）조급생맥주사액치료조황조。동태관찰혈장염증개질내독소（LPs）、종류배사인자（TNF-α）、백세포개소-6，8（IL-6，IL-8）、내피소（ET）이급신장공능지표뇨전철단백（TFR）、뇨백단백（ALB）급뇨시황순（RBP）적변화。결과：생맥주사액치료조술후7천여술후1천상비，LPs、IL-6、IL-8、ET、TNF-α、TFR、RBP、ALB명현하강（P<0.05〉，차저우혹접근술전수평，황달대조조재술후7천여술후1천상비무현저차이（P>0.05）。결론：생맥주사액대조황환자술후LPs유길항작용，동시강저기타염증개질수평，령외환구유보호신장공능적작용。
OBJECTIVE:To investigate the effect of Shengmai injection on inflammatory mediator and renal injury in obstructive jaundice.METHODS:The patients with obstructive jaundice were randomly divided into 2 groups. 15 cases of non-jaundiced patients as another control group according to preoperative arrangement. The plasma ET, LPs, TNF-а, IL-6, IL-8 and urine RBP, TFR, ALB were measured pre and post operative 1, 4, 7 days.RESULTS:LPs , TNF-а, IL-6, IL-8, ET, RBP, TFR and ALB level of Shengmai injection group during post-operative 7 day were obviously lowered as compared with the same group during post-operative 1 day(P<0.05).CONCLUSION:post-operative uses of Shengmai injection might effectively decrease the post-operative level of plasma LPs, ET, TNF-α and IL-6，IL-8. At the mean time, Shengmai injection may protect renal function by inhibiting inflammatory mediator and improving blood dynamics.