CAJ | 학술논문

以多巴胺D2受体配体Cl-ABZM为前体，合成了末端带有巯基的单齿化合物，光谱数据与结构相符.用配体交换法与3-硫杂-1，5-戊二硫醇共同配位合成了“3+1”型混配螯合物，对影响标记率的诸多因素如pH值、温度、配体用量及反应时间等进行了优化，得到最佳标记条件，标记率大于85%.
이다파알D2수체배체Cl-ABZM위전체，합성료말단대유구기적단치화합물，광보수거여결구상부.용배체교환법여3-류잡-1，5-무이류순공동배위합성료“3+1”형혼배오합물，대영향표기솔적제다인소여pH치、온도、배체용량급반응시간등진행료우화，득도최가표기조건，표기솔대우85%.
In developing 99mTc-labeled dopamine D2 receptor imaging agents,a new substituted benzamide compound is designed and synthesized. By tetering a S3 chelate system onto it, a technetium 3+1 complex is formed.Initial synthesis and radiolabeling suggest that the 99mTc complex is neutral and lipophilic.The factors which have influence on labeling yield are optimized, including pH value, ligand quantity, reaction temperature and time. Labeling yield is over 85%.