CAJ | 학술논문

提出了测定盐酸洛美沙星(LMX)的萃取分光光度法，该法基于在弱酸性条件下，盐酸洛美沙星与溴甲酚绿(BMG)反应生成可被三氯甲烷萃取的离子对缔合物，其最大吸收波长为415nm。药物浓度在l～15mg/L(r=0.9997)范围内符合比耳定律。表观摩尔吸收系数ε=2.5×104L·mol-1·m-1。最低检出限为0.014mg/L。回收率为98.9％～101.6％。该法可成功的用于药物制剂中洛美沙星含量的测定。
제출료측정염산락미사성(LMX)적췌취분광광도법，해법기우재약산성조건하，염산락미사성여추갑분록(BMG)반응생성가피삼록갑완췌취적리자대체합물，기최대흡수파장위415nm。약물농도재l～15mg/L(r=0.9997)범위내부합비이정률。표관마이흡수계수ε=2.5×104L·mol-1·m-1。최저검출한위0.014mg/L。회수솔위98.9％～101.6％。해법가성공적용우약물제제중락미사성함량적측정。
Extraction-spectrophotometric method for determination of lomefloxacin is proposed.The ion pairs complex of lomefloxacin with brornocresol green (BMG) can be extracted into CHCI3 at pH 3.6 and has absorption maximum at 415nm.The calibrationgraphs generated was linear over the range of 1～15mg/L drug in solution (r=0.9997).ε=2.5×104L·mol-1·cm-1.The detection limit is 0.014mg/L.The recovery of method is 98.9%～101.6%.The proposed method has been successfully applied to the determination of lomefloxacin in pharmaceutical formulations.