CAJ | 학술논문

目的:研究阿司匹林铜(CuAsp)抗血栓作用及对花生四烯或凝血酶激活的血小板与中性粒细胞粘附的抑制作用,从而探讨其抗血栓机制。方法:采用静注花生四烯酸致小鼠肺微血管栓塞死亡和玫瑰花结形成试验。结果:CuAsp可明显降低静注花生四烯酸造成的小鼠肺微血管广泛性血小板血栓形成而导致呼吸衰竭的死亡率,不同浓度的 CuAsp均可抑制花生四烯酸或凝血酶激活的血小板与中性粒细胞的粘附作用, IC50分别为41.5 μmol.L-1和54.6 μmol.L-1。结论:CuAsp可通过抑制血小板与中性粒细胞间的粘附而产生抗血栓作用。
목적:연구아사필림동(CuAsp)항혈전작용급대화생사희혹응혈매격활적혈소판여중성립세포점부적억제작용,종이탐토기항혈전궤제。방법:채용정주화생사희산치소서폐미혈관전새사망화매괴화결형성시험。결과:CuAsp가명현강저정주화생사희산조성적소서폐미혈관엄범성혈소판혈전형성이도치호흡쇠갈적사망솔,불동농도적 CuAsp균가억제화생사희산혹응혈매격활적혈소판여중성립세포적점부작용, IC50분별위41.5 μmol.L-1화54.6 μmol.L-1。결론:CuAsp가통과억제혈소판여중성립세포간적점부이산생항혈전작용。
To study the effects of copper-aspirin complex (CuAsp) on thrombosis and on platelet-neutrophile adhesion.METHODS:The methods of Kohier et al. and Hamburger et al. and Jungi et al. were applied to observe the effects of CuAsp on thrombosis in mice and platelet-neutrophile adhesion in rats. RESULTS:CuAsp 10 mg.kg-1.d ig for 7d markedly decreased the male mouse mortality caused by injection of 80 mg.kg-1arachidonic acid in the tail vein from 80.0% in vehicle group to 13.3%. CuAsp also significantly inhibited the adhesion of neutrophiles to platelets activated by arachidonic acid or thrombin in vitro, IC50 were 41.5 and 54.6 μmol.L-1.CONCLUSION:It is demonstrated that CuAsp inhibited platelet-neutrophile adhesion and resulted in more potent antithrombotic activity