CAJ | 학술논문

本文简述了同源框基因（HOX）和SOX基因两大家族的特征及其在发育过程中的作用。个体发育从受精卵开始就受发育调控串基因的有序启动与关闭的控制。基因表达的调节主要在转录水平上进行，并且转录调控子多是一类DNA结合蛋白，通过其与受控基因启动子或其他调控元件的结合来调节目标基因的表达。HOX、SOX和DMRT基因三大家族正是通过上述机制参与广泛的发育调控过程。
본문간술료동원광기인（HOX）화SOX기인량대가족적특정급기재발육과정중적작용。개체발육종수정란개시취수발육조공천기인적유서계동여관폐적공제。기인표체적조절주요재전록수평상진행，병차전록조공자다시일류DNA결합단백，통과기여수공기인계동자혹기타조공원건적결합래조절목표기인적표체。HOX、SOX화DMRT기인삼대가족정시통과상술궤제삼여엄범적발육조공과정。
This paper reviews two families of genes (homeotic genes and SOX genes) and their roles in regulating development.The development of an adult organism begins with a single fertilized egg following a predetermined cascade of control,in which specific genes are turned on and off at particular times.The principal level for controlling gene expression is at transcription and the regulators of transcription are often DNA-binding proteins that activate transcription at particular promotors or other regulatory regions.By regulating transcription,these two families of genes play essential roles in a variety of developmental processes.