CAJ | 학술논문

DNA甲基化是表观遗传学的重要部分,同组蛋白修饰相互作用,通过改变染色质结构,调控基因表达.在哺乳类细胞或人体细胞中,DNA甲基化与细胞的增殖、衰老、癌变等生命现象有着重大关系.对催化DNA甲基化的DNA甲基转移酶(DNA methyltransferase,Dnmt)的研究可以揭示DNA甲基化对基因表达调控的机制,从而研究与之相关的重要生命活动.文章以DNA甲基转移酶作为切入点,探讨DNA甲基转移酶在基因表达调控中发挥的作用及其主要生物学功能.
DNA갑기화시표관유전학적중요부분,동조단백수식상호작용,통과개변염색질결구,조공기인표체.재포유류세포혹인체세포중,DNA갑기화여세포적증식、쇠로、암변등생명현상유착중대관계.대최화DNA갑기화적DNA갑기전이매(DNA methyltransferase,Dnmt)적연구가이게시DNA갑기화대기인표체조공적궤제,종이연구여지상관적중요생명활동.문장이DNA갑기전이매작위절입점,탐토DNA갑기전이매재기인표체조공중발휘적작용급기주요생물학공능.
Both hitone modification and DNA methylation remodulate chromatin structure and control gene expression or silence. As a main enzyme for DNA methylation, DNA methyltransferase (Dnmt) is not only associated with DNA methylation, but also links to many important biological activities, including cell proliferation, senescence and cancer development. This review focuses on structure, regulation and function in biological processes of Dnmt.