中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2009年
21期
2-3,5
,共3页
西酞普兰%帕罗西汀%脑卒中后抑郁症
西酞普蘭%帕囉西汀%腦卒中後抑鬱癥
서태보란%파라서정%뇌졸중후억욱증
Citalopram%Paroxetine%Post-stroke depression
目的 评价西酞普兰和帕罗西汀治疗脑卒中后抑郁症(PSD)的临床疗效和安全性.方法 将56例脑卒中后抑郁症患者采用随机方法 分成两组,分别给予西酞普兰与帕罗西汀治疗6周,采用汉密顿抑郁量表(HAMD)和副反应量表(TESS)对治疗前后的情况进行比较分析.结果 西酞普兰组显效率78.57%,帕罗西汀组显效率75.0%,2组间相比差异无统计学意义(P＞0.05);治疗前后相比,西酞普兰及帕罗西汀组HAMD总分均有显著下降(P＜0.01),差异有统计学意义;不良反应发生率西酞普兰组42.9%,帕罗西汀组46.4%,两组比较无统计学意义(P＞0.05).结论 西酞普兰和帕罗西汀治疗脑卒中后抑郁症均安全有效.
目的 評價西酞普蘭和帕囉西汀治療腦卒中後抑鬱癥(PSD)的臨床療效和安全性.方法 將56例腦卒中後抑鬱癥患者採用隨機方法 分成兩組,分彆給予西酞普蘭與帕囉西汀治療6週,採用漢密頓抑鬱量錶(HAMD)和副反應量錶(TESS)對治療前後的情況進行比較分析.結果 西酞普蘭組顯效率78.57%,帕囉西汀組顯效率75.0%,2組間相比差異無統計學意義(P＞0.05);治療前後相比,西酞普蘭及帕囉西汀組HAMD總分均有顯著下降(P＜0.01),差異有統計學意義;不良反應髮生率西酞普蘭組42.9%,帕囉西汀組46.4%,兩組比較無統計學意義(P＞0.05).結論 西酞普蘭和帕囉西汀治療腦卒中後抑鬱癥均安全有效.
목적 평개서태보란화파라서정치료뇌졸중후억욱증(PSD)적림상료효화안전성.방법 장56례뇌졸중후억욱증환자채용수궤방법 분성량조,분별급여서태보란여파라서정치료6주,채용한밀돈억욱량표(HAMD)화부반응량표(TESS)대치료전후적정황진행비교분석.결과 서태보란조현효솔78.57%,파라서정조현효솔75.0%,2조간상비차이무통계학의의(P＞0.05);치료전후상비,서태보란급파라서정조HAMD총분균유현저하강(P＜0.01),차이유통계학의의;불량반응발생솔서태보란조42.9%,파라서정조46.4%,량조비교무통계학의의(P＞0.05).결론 서태보란화파라서정치료뇌졸중후억욱증균안전유효.
Objective To study the efficacy and safety of citalopram and paroxetine in the treatment of post-stroke depression Methods 56 patients with post-stroke depression were divided into two groups with citaloprom or paroxetine for 6 weeks respectively.The therapentic responses were evaluated with HAMD and TESS. Results Excellence rates were respectively 78.57% in citalopram and 75% in the paroxetine group, which showed no significant difference (P>0.05); The scores of HAMD decreased more markedly after the treatment than before the treatment in two groups(P<0.01); incidences of adverse effects were respectively 42.9% in the citalopram arm and 42.9% in the paroxetine group,difference was not significant(P>0.05),Conclusion In the treatment of post-stroke depression,citalopram and paroxitine all have good curative effects, and have light side effects.
