CAJ | 학술논문

目的:观察长托宁和新斯的明用于残余肌松拮抗的临床效果.方法:随机选择75例手术患者分成长托宁0.01 mg/kg+新斯的明0.02 mg/kg(A组),长托宁0.015 mg/kg和新斯的明0.02 mg/kg(B组),阿托品0.01 mg/kg+新斯的明0.02 mg/kg(C组).术毕患者有轻微呼吸后分别给予上述混合药物.记录给药前(TD),给药后2min(T1),5min(T2),10min(T3),15min(T4)的MAP、HR、RPP、肌力、唾液分泌量、口干评分及不良反应.结果:3组MAP、肌力、唾液分泌量、口干评分无明显差异;HR,RPP在C组同A、B组在T1,T2,13差异有显著性(P<0.01),与本组T0相比差异有显著性(P<0.01);B组HR在T1、T2、T3与本组T0相比有明显下降(P<0.05).结论:长托宁0.01mg/kg+新斯的明0.02 mg/kg用于术毕拮抗残余肌松效果良好,不良作用轻微,其比例适当临床运用安全有效.
목적:관찰장탁저화신사적명용우잔여기송길항적림상효과.방법:수궤선택75례수술환자분성장탁저0.01 mg/kg+신사적명0.02 mg/kg(A조),장탁저0.015 mg/kg화신사적명0.02 mg/kg(B조),아탁품0.01 mg/kg+신사적명0.02 mg/kg(C조).술필환자유경미호흡후분별급여상술혼합약물.기록급약전(TD),급약후2min(T1),5min(T2),10min(T3),15min(T4)적MAP、HR、RPP、기력、타액분비량、구간평분급불량반응.결과:3조MAP、기력、타액분비량、구간평분무명현차이;HR,RPP재C조동A、B조재T1,T2,13차이유현저성(P<0.01),여본조T0상비차이유현저성(P<0.01);B조HR재T1、T2、T3여본조T0상비유명현하강(P<0.05).결론:장탁저0.01mg/kg+신사적명0.02 mg/kg용우술필길항잔여기송효과량호,불량작용경미,기비례괄당림상운용안전유효.
Objective:To investigate the clinical effect of penehyclidine hydrochloride(PH) combined with neostigmine(NG) reversing residucl muscular relaxation for general anesthesia. Methods:Seventy-five patients for general anesthesia were randomly divided into three groups with twenty-five cases each.The patients in group A received PH 0.01 mg/kg+NG 0.02 mg/kg, PH 0.015 mg/kg+NG 0.02 mg/ kg in group B and atropine 0.01 mg/kg+NG 0.02 mg/kg in group C.Having voluntary respiration after the completion of surgery,above mentioned intermixture were given intravenously to reverse the residual muscular relaxation.HR, MAP,RPP,salivary secretion and side effects were assessed before drug administration (T0),at 2min(T1),5min(T2), 10min(T3), 15min(T4) alter drug administration. Results:HR and RPP were significantly different in group A and B at T1 ,T2 ,T3 compared to those in group C. HR in group B at T1 ,T2 ,T3 was sig-nificantly declined to that of T0 .Conclusion:PH 0.01 mg/kg+NG 0.02 mg/kg can be used with good effect and less side effect.