现代中西医结合杂志
現代中西醫結閤雜誌
현대중서의결합잡지
MODERN JOURNAL OF INTEGRATED TRADITIONAL CHINESE AND WESTERN MEDICINE
2014年
12期
1273-1275
,共3页
郭明丽%陈红耀%韩晓丽%张洪珍
郭明麗%陳紅耀%韓曉麗%張洪珍
곽명려%진홍요%한효려%장홍진
参芪扶正注射液%头颈部肿瘤%放疗%化疗%生活质量
參芪扶正註射液%頭頸部腫瘤%放療%化療%生活質量
삼기부정주사액%두경부종류%방료%화료%생활질량
Shenqi Fuzheng injection%head and neck cancer%radiaotherapy%chemotherapy%quality of life
目的:观察参芪扶正注射液联合同步放化疗对头颈部肿瘤患者生活质量的影响。方法将70例头颈部肿瘤患者根据治疗方式不同分为对照组与治疗组。对照组35例采用三维适形放疗同步联合PF方案化疗及对症支持治疗,治疗组35例同时加用参芪扶正注射液250 mL/d静滴。治疗结束时评估2组患者体质量、KPS评分及放化疗不良反应发生率。结果治疗结束时,治疗组与对照组体质量增加稳定率及KPS有效率分别为91%和69%,86%和63%,2组比较有显著性差异( P<0.05)。治疗组Ⅱ级以上血液学毒性、消化道反应、放射性皮肤损伤及口腔溃疡发生率均低于对照组( P均<0.05)。治疗组治疗后CD3、CD4、CD4/CD8水平较治疗前及对照组升高( P均<0.05)。结论参芪扶正注射液联合放化疗治疗头颈部肿瘤,可改善患者生活质量,减轻放化疗毒副反应,提高免疫力,值得临床推广。
目的:觀察參芪扶正註射液聯閤同步放化療對頭頸部腫瘤患者生活質量的影響。方法將70例頭頸部腫瘤患者根據治療方式不同分為對照組與治療組。對照組35例採用三維適形放療同步聯閤PF方案化療及對癥支持治療,治療組35例同時加用參芪扶正註射液250 mL/d靜滴。治療結束時評估2組患者體質量、KPS評分及放化療不良反應髮生率。結果治療結束時,治療組與對照組體質量增加穩定率及KPS有效率分彆為91%和69%,86%和63%,2組比較有顯著性差異( P<0.05)。治療組Ⅱ級以上血液學毒性、消化道反應、放射性皮膚損傷及口腔潰瘍髮生率均低于對照組( P均<0.05)。治療組治療後CD3、CD4、CD4/CD8水平較治療前及對照組升高( P均<0.05)。結論參芪扶正註射液聯閤放化療治療頭頸部腫瘤,可改善患者生活質量,減輕放化療毒副反應,提高免疫力,值得臨床推廣。
목적:관찰삼기부정주사액연합동보방화료대두경부종류환자생활질량적영향。방법장70례두경부종류환자근거치료방식불동분위대조조여치료조。대조조35례채용삼유괄형방료동보연합PF방안화료급대증지지치료,치료조35례동시가용삼기부정주사액250 mL/d정적。치료결속시평고2조환자체질량、KPS평분급방화료불량반응발생솔。결과치료결속시,치료조여대조조체질량증가은정솔급KPS유효솔분별위91%화69%,86%화63%,2조비교유현저성차이( P<0.05)。치료조Ⅱ급이상혈액학독성、소화도반응、방사성피부손상급구강궤양발생솔균저우대조조( P균<0.05)。치료조치료후CD3、CD4、CD4/CD8수평교치료전급대조조승고( P균<0.05)。결론삼기부정주사액연합방화료치료두경부종류,가개선환자생활질량,감경방화료독부반응,제고면역력,치득림상추엄。
Objective It is to observe the influence of Shenqi Fuzheng injection combined with radio -chemotherapy on quality of life in head and neck cancer patients .Methods 70 patients with head and neck cancer were divided into control group and treatment group .35 patients in control group were treated with dimensional conformal radiotherapy combined with chemotherapy of PF and symptomatic and supportive treatment .35 patients in treatment group were treated as control group , and combined with Shenqi Fuzheng injection 250 mL/d at the same time.After treatment, the changes of weight , KPS score and the incidence of adverse reactions of radiotherapy and chemotherapy in two groups were compared .Results After treatment, the increased stability rate of the weight and the effective rate of KPS score in treatment group and control group was 91 .4%and 68.6%, 85.7%and 62.9%respectively, there were significant differences (all P<0.05).The incidence of hematolog-ical toxicity , gastrointestinal reaction , radiation injury of skin and the oral cavity ulcer above grade II in treatment group was lower than that in control group, there was significant difference(P<0.05).The levels of CD3, CD4 and the value of CD4/CD8 in treatment group post-treatment was improved compared with pre -treatment and control group (all P<0.05).Conclu-sion The treatment of Shenqi Fuzheng injection combined with radio-chemotherapy for the patients with head and neck cancer can improve the quality of life of them , reduce the incidence of toxic side effects of radiotherapy and chemotherapy .It is wor-thy to clinical promotion .