中外健康文摘
中外健康文摘
중외건강문적
WORLD HEALTH DIGEST
2009年
18期
55-56
,共2页
PTEN基因%骨巨细胞瘤%mRNA
PTEN基因%骨巨細胞瘤%mRNA
PTEN기인%골거세포류%mRNA
PTEN giant cell tumors of bone mRNA%RT-PCR
目的 研究骨巨细胞瘤中PTEN基因的表达情况、探讨其与骨巨细胞瘤临床分级和预后的关系. 方法 应用RT-PCR的方法检测了32例骨巨细胞瘤PTEN mRNA的表达,就PTEN mRNA表达水平与临床变量之间进行分析.结果 PTEN mRNA在骨巨细胞瘤中的阳性表达率为75%;PTEN mRNA阳性表达与患者的年龄、性别和Jaffe分级无关;与Enneking分级和肿瘤复发转移有相关性( P <0.05),与生存时间显著相关(P <0.01).结论 PTEN mRNA在骨巨细胞瘤中的表达与Enneking分级和预后有一定关系,可以作为判断骨巨细胞瘤预后的一项重要参考指标.
目的 研究骨巨細胞瘤中PTEN基因的錶達情況、探討其與骨巨細胞瘤臨床分級和預後的關繫. 方法 應用RT-PCR的方法檢測瞭32例骨巨細胞瘤PTEN mRNA的錶達,就PTEN mRNA錶達水平與臨床變量之間進行分析.結果 PTEN mRNA在骨巨細胞瘤中的暘性錶達率為75%;PTEN mRNA暘性錶達與患者的年齡、性彆和Jaffe分級無關;與Enneking分級和腫瘤複髮轉移有相關性( P <0.05),與生存時間顯著相關(P <0.01).結論 PTEN mRNA在骨巨細胞瘤中的錶達與Enneking分級和預後有一定關繫,可以作為判斷骨巨細胞瘤預後的一項重要參攷指標.
목적 연구골거세포류중PTEN기인적표체정황、탐토기여골거세포류림상분급화예후적관계. 방법 응용RT-PCR적방법검측료32례골거세포류PTEN mRNA적표체,취PTEN mRNA표체수평여림상변량지간진행분석.결과 PTEN mRNA재골거세포류중적양성표체솔위75%;PTEN mRNA양성표체여환자적년령、성별화Jaffe분급무관;여Enneking분급화종류복발전이유상관성( P <0.05),여생존시간현저상관(P <0.01).결론 PTEN mRNA재골거세포류중적표체여Enneking분급화예후유일정관계,가이작위판단골거세포류예후적일항중요삼고지표.
Objective To study the expression of PTEN gene and its relationship with the clinical grades and evaluation of clinical prognosis in giant cell tumors of bone. Method The PTEN gene mRNA was investigated by using RT-PCR in 32 cases with giant cell tumors of bone. The analysis were carried out between the level of PTEN mRNA expressin and the clinical variable.Results The PTEN gene mRNA positive expression rate was 75% in giant cell tumors of bone;the positive expression rate of PTEN mRNA was correlated with Enneking's stages and recurrence and metastasis (P<0.05) .The positive expression rate was significantly related with patient's survival time(P<0.01),but was no associated with patient's age,sex and Jaffe's grade.Conclusion The PTEN gene mRNA positive expression rate was related with clinical prognosis and Enneking's stages and may be an important parameter in predicting behavior in giant cell tumors of bone.
