中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2014年
18期
36-36,38
,共2页
贝那普利%缬沙坦%早期糖尿病肾病
貝那普利%纈沙坦%早期糖尿病腎病
패나보리%힐사탄%조기당뇨병신병
Benazepril%Valsartan%Early diabetic nephropathy
目的：探讨贝那普利联合缬沙坦治疗早期糖尿病肾病的临床疗效及对UAE的影响。方法：2012年4月-2013年4月收治早期糖尿病肾病患者120例，作为研究对象。随机将患者分为A、B、C三组，每组40例。其中A组单独采用贝那普利作为治疗用药；B组单独采用缬沙坦作为治疗用药；C组采取贝那普利联合缬沙坦作为治疗用药，比较三组在治疗前后，组与组之间的差异和在4、8、12周后的UAE变化情况，并采取统计学方式进行处理分析。结果：三组患者在治疗后的UAE值都得到了明显的改善，其中C组的总治疗有效率达到了90%，相比较B组65%和A组75%差异均有统计学意义(P＜0.05)。从治疗时间上来分析，第4周开始，三组患者的UAE都持续下降，并在第12周时效果最为明显。从下降趋势上，C组效果要优于A组和B组，且差异具有统计学意义(P＜0.05)。结论：采取贝那普利联合缬沙坦治疗早期糖尿病肾病效果显著，值得推广。
目的：探討貝那普利聯閤纈沙坦治療早期糖尿病腎病的臨床療效及對UAE的影響。方法：2012年4月-2013年4月收治早期糖尿病腎病患者120例，作為研究對象。隨機將患者分為A、B、C三組，每組40例。其中A組單獨採用貝那普利作為治療用藥；B組單獨採用纈沙坦作為治療用藥；C組採取貝那普利聯閤纈沙坦作為治療用藥，比較三組在治療前後，組與組之間的差異和在4、8、12週後的UAE變化情況，併採取統計學方式進行處理分析。結果：三組患者在治療後的UAE值都得到瞭明顯的改善，其中C組的總治療有效率達到瞭90%，相比較B組65%和A組75%差異均有統計學意義(P＜0.05)。從治療時間上來分析，第4週開始，三組患者的UAE都持續下降，併在第12週時效果最為明顯。從下降趨勢上，C組效果要優于A組和B組，且差異具有統計學意義(P＜0.05)。結論：採取貝那普利聯閤纈沙坦治療早期糖尿病腎病效果顯著，值得推廣。
목적：탐토패나보리연합힐사탄치료조기당뇨병신병적림상료효급대UAE적영향。방법：2012년4월-2013년4월수치조기당뇨병신병환자120례，작위연구대상。수궤장환자분위A、B、C삼조，매조40례。기중A조단독채용패나보리작위치료용약；B조단독채용힐사탄작위치료용약；C조채취패나보리연합힐사탄작위치료용약，비교삼조재치료전후，조여조지간적차이화재4、8、12주후적UAE변화정황，병채취통계학방식진행처리분석。결과：삼조환자재치료후적UAE치도득도료명현적개선，기중C조적총치료유효솔체도료90%，상비교B조65%화A조75%차이균유통계학의의(P＜0.05)。종치료시간상래분석，제4주개시，삼조환자적UAE도지속하강，병재제12주시효과최위명현。종하강추세상，C조효과요우우A조화B조，차차이구유통계학의의(P＜0.05)。결론：채취패나보리연합힐사탄치료조기당뇨병신병효과현저，치득추엄。
Objective:To explore the curative effect and effect on UAE of benazepril combined with valsartan in the treatment of early diabetic nephropathy.Methods:120 cases with early diabetic nephropathy were selected from April 2012 to April 2013.They were as the research objects.They were randomly divided into A,B,C three groups with 40 cases in each.A group were alone treated with benazepril.B group were alone treated with valsartan.C were treated with benazepril combined with valsartan.The differences between the groups before and after treatment were compared.The changes of UAE after 4,8,12 weeks were compared. It took statistical approach for processing analysis.Results:After the treatment,the UAE of the three groups were obviously improved.The total treatment effectiveness of C group reached 90%.There were significant differences compared with 65% of B group and 75% of A group(P<0.05).From the time of treatment to analyze,the UAE of the three groups were continued decline on the begin of the fourth week.The effect of the twelfth week was most obvious.In the decreasing trend,the effect of C group was better than that of A group and B group.The difference was statistically significant(P<0.05).Conclusion:The benazepril combined with valsartan in the treatment of patients with early diabetic nephropathy has a significant effect.It is worthy of promotion.
