CAJ | 학술논문

目的观察埃索美拉唑、左氧氟沙星联合阿莫西林治疗幽门螺杆菌感染的胃溃疡的临床疗效。方法将80例有幽门螺杆菌感染的胃溃疡患者随机分为两组：治疗组采用埃索美拉唑20mg、左氧氟沙星200mg、阿莫西林1000mg,均2次/d，治疗7d；之后溃疡患者继续用埃索美拉唑20mg,1次/d，共3周；对照组采用奥美拉唑20mg，左氧氟沙星和阿莫西林剂量同前，治疗7d；之后溃疡患者继续用奥美拉唑20mg,1次/d，共3周；4周后复查，观察腹痛缓解率、胃粘膜溃疡改善情况及Hp根除率、不良反应。结果治疗组与对照组腹痛缓解率、胃粘膜溃疡改善率比较差异有统计学意义(P<0.05)。Hp根除率分别为92.5%和89%，不良反应率相似，两组比较无统计学意义(P>0.05)。结论埃索美拉唑三联疗法治疗胃溃疡的疗效优于奥美拉唑三联疗法，值得推广使用。
목적관찰애색미랍서、좌양불사성연합아막서림치료유문라간균감염적위궤양적림상료효。방법장80례유유문라간균감염적위궤양환자수궤분위량조：치료조채용애색미랍서20mg、좌양불사성200mg、아막서림1000mg,균2차/d，치료7d；지후궤양환자계속용애색미랍서20mg,1차/d，공3주；대조조채용오미랍서20mg，좌양불사성화아막서림제량동전，치료7d；지후궤양환자계속용오미랍서20mg,1차/d，공3주；4주후복사，관찰복통완해솔、위점막궤양개선정황급Hp근제솔、불량반응。결과치료조여대조조복통완해솔、위점막궤양개선솔비교차이유통계학의의(P<0.05)。Hp근제솔분별위92.5%화89%，불량반응솔상사，량조비교무통계학의의(P>0.05)。결론애색미랍서삼련요법치료위궤양적료효우우오미랍서삼련요법，치득추엄사용。
Objective To observe the clinical effect of esomeprazole, levofloxacin and amoxicillin in the treatment of Helicobacter pylori infection and gastric ulcer. Methods 80 patients with gastric ulcer patients with Helicobacter pylori infection were randomly divided into two groups: the treatment group treated with esomeprazole, levofloxacin, amoxicillin 20mg 200mg 1000mg, 2 /d, 7d after treatment; ulcer patients continue with esomeprazole 20mg, 1 times /d, a total of 3 weeks; the control group used 20mg omeprazole, levofloxacin and amoxicillin dose ibid, treatment of 7D; after ulcer patients continue with omeprazole 20mg, 1 times /d, a total of 3 weeks; 4 weeks, to observe the abdominal pain remission rate, gastric mucosal ulcer improved and Hp eradication rate, adverse reaction. Results the treatment group and the control ease the difference rate, improvement rate of abdominal pain of gastric mucosa ulcer group had statistical significance (P<0.05). Hp eradication rates were 92.5% and 89%, the adverse reaction rates were similar, the two groups had no statistical significance ( P>0.05 ). Conclusionesomeprazole triple therapy in the treatment of gastric ulcer curative effect is better than that of omeprazole triple therapy, is worthy to be popularized.