CAJ | 학술논문

目的观察盐酸氨基葡萄糖治疗维持性血液透析患者伴发膝骨关节炎的临床疗效。方法维持性血液透析患者伴发膝骨关节炎28例随机分为2组，治疗组13例给予盐酸氨基葡萄糖胶囊0.75 bid；对照组15例给予洛索洛芬钠60mg tid治疗，疗程均6周。观察治疗前、治疗6周后的临床疗效指标、不良反应情况。结果6周时2组患者临床疗效指标较治疗前均显著改善(P均<0.05)；治疗组改善程度优于对照组(P<0.05)，治疗过程中，两组患者均未发生严重不良反应，但对照组胃肠道不良反应发生率明显高于治疗组。两组比较差异有统计学意义。结论盐酸氨基葡萄糖治疗维持性血液透析患者伴发膝骨关节炎安全有效，不良反应轻微，可作为一种可行的方法。
목적관찰염산안기포도당치료유지성혈액투석환자반발슬골관절염적림상료효。방법유지성혈액투석환자반발슬골관절염28례수궤분위2조，치료조13례급여염산안기포도당효낭0.75 bid；대조조15례급여락색락분납60mg tid치료，료정균6주。관찰치료전、치료6주후적림상료효지표、불량반응정황。결과6주시2조환자림상료효지표교치료전균현저개선(P균<0.05)；치료조개선정도우우대조조(P<0.05)，치료과정중，량조환자균미발생엄중불량반응，단대조조위장도불량반응발생솔명현고우치료조。량조비교차이유통계학의의。결론염산안기포도당치료유지성혈액투석환자반발슬골관절염안전유효，불량반응경미，가작위일충가행적방법。
0bjective To observe the therapeutic effectiveness and safety of glucosamine hydrochloride capsule in the treatment of knee osteoarthritis(KOA) with maintenance hemodialysis(MHD).Methods Twenty-eight patients with knee osteoarthritis were selected from the Department of blood purifying center between May 2011 and May 2012.They were assigned randomly to treatment group and control group ,each 13 and 15 patients, The treatment group were treated with oral glucosamine hydrochloride capsule twice a day for 6 continuous weeks, each capsules750 mg.and the control group were given loxoprofen sodium three times a day ,each 60 mg, also for 6 continuous weeks .After two courses of treatment,the international standard DOA score of Lequesne index was used to evaluate clinical efficacy, and the adverse reactions were also observed. Results All 28 patients finished treatment after 6 weeks,Clinical manifestation of the two groups were improved(P<0.05), the treatment group were very significant differences with the control group (P<0.05) . and adverse drug effects of two are mild ,Only 6 of the 28 subjects had mild side effects,the rate of gastrointestinal reaction in the control group was significant higher than that of the treatment group(P<0.05).Conclusion Glucosamine hydrochloride have effectiveness and safety in the treatment of KOA with maintenance hemodialysis