CAJ | 학술논문

目的糖尿病视网膜病变（diabetic retinopathy，DR）是常见的由糖尿病并发的眼部新生血管性疾病，是严重的致盲性眼病。DR的发病机制尚不明确，近年来研究表明，多种细胞因子在发病过程中起重要作用。本文就血管内皮生长因子、胰岛素样生长因子-1、碱性成纤维细胞生长因子、转化生长因子-β、肿瘤坏死因子、色素上皮衍生因子等多种细胞因子在DR中的作用进行综述。
목적당뇨병시망막병변（diabetic retinopathy，DR）시상견적유당뇨병병발적안부신생혈관성질병，시엄중적치맹성안병。DR적발병궤제상불명학，근년래연구표명，다충세포인자재발병과정중기중요작용。본문취혈관내피생장인자、이도소양생장인자-1、감성성섬유세포생장인자、전화생장인자-β、종류배사인자、색소상피연생인자등다충세포인자재DR중적작용진행종술。
Diabetic retinopathy(DR) is a common neovasculardiseasesecondary to diabetes mellitus and causes of blindness. The pathogenesis are associated withmultiple ceIluIar factors,such asvascularendothelial growth factor(VEGF), insulin-like growth factor-1(IGF-1), basic fibroblast growth factor(bFGF), transforming growth factor-β(TGF-β), tumor necrosis factor(TNF), pigment epithelium-derived factor(PEDF), etc.This article reviewed the advance in this correlation cytokine.