CAJ | 학술논문

目的探讨Cystatin C对终末期肾病（ESRD）患者的左心室结构、功能及大动脉硬化的影响及作用机制。方法选取2012年8月至12月大连市中心医院透析中心血液透析患者31例，测定Cystatin C及常见生化指标，用超声心动图分别测定心脏结构和功能指标，包括左心房内径（LAD）、左心室舒张末期内径（LVDd）、左心室后壁厚度（LVPWT）、室间隔厚度（IVST）、舒张早期及晚期最大血流比（E/A）及等容舒张时间（IRT），并相应推算射血分数（EF），根据Devereux和Reichek公式计算左心室心肌重量指数（LVMI），同时测定肱踝动脉脉搏波速度；应用SPSS16.0统计软件进行相关性分析。结果 Cystatin C与LVDd呈正相关，ESRD患者PWV明显升高，与年龄和TG呈正相关，与Cystatin C无统计学意义。结论 Cystatin C参与ESRD患者左心结构异常，可能是预测ESRD患者心血管疾病的指标之一。
목적탐토Cystatin C대종말기신병（ESRD）환자적좌심실결구、공능급대동맥경화적영향급작용궤제。방법 선취2012년8월지12월대련시중심의원투석중심혈액투석환자31례，측정Cystatin C급상견생화지표，용초성심동도분별측정심장결구화공능지표，포괄좌심방내경（LAD）、좌심실서장말기내경（LVDd）、좌심실후벽후도（LVPWT）、실간격후도（IVST）、서장조기급만기최대혈류비（E/A）급등용서장시간（IRT），병상응추산사혈분수（EF），근거Devereux화Reichek공식계산좌심실심기중량지수（LVMI），동시측정굉과동맥맥박파속도；응용SPSS16.0통계연건진행상관성분석。결과 Cystatin C여LVDd정정상관，ESRD환자PWV명현승고，여년령화TG정정상관，여Cystatin C무통계학의의。결론 Cystatin C삼여ESRD환자좌심결구이상，가능시예측ESRD환자심혈관질병적지표지일。
Objective: To investigate the influence and mechanism of Cystatin C for left ventricular structure, function and atherosclerosis in end-stage renal disease (ESRD) patients. Methods: 31 cases hemodialysis patients from August to December, 2012, Dalian Central Hospital dialysis center were involved. Cystatin C,biochemical indicators ,cardiac structure and function indicators and brachial ankle arterial pulse wave velocity were measured, including left atrium inside diameter (LAD) , left ventricular end-diastolic diameter (LVDd), left ventricular posterior wall thickness (LVPWT), ventricular septal thickness (IVST), early diastolic and late maximum blood flow ratio (E / A) and isovolumic relaxation time (IRT), and the corresponding projections ejection fraction (EF). Left ventricular mass index (LVMI) were calculated according to Devereux and Reichek formula. Results: Person correlation analysis showed that Cystatin C positively correlated with LVDd and PWV in ESRD patients increased and positively correlated with age and TG ,but not Cystatin C. Conclusion: Cystatin C in ESRD patients with left ventricular structural abnormalities and may predict cardiovascular disease in ESRD patients