中外健康文摘
中外健康文摘
중외건강문적
WORLD HEALTH DIGEST
2013年
19期
90-90,91
,共2页
阴囊神经性皮炎%他克莫司软膏%抗焦虑药
陰囊神經性皮炎%他剋莫司軟膏%抗焦慮藥
음낭신경성피염%타극막사연고%항초필약
Neurodermatitis%Tacrolimus ointment%Antianxiety agrnts
目的探讨0.1%他克莫司软膏联合帕罗西汀治疗阴囊神经性皮炎的临床疗效。方法选择70例伴失眠的阴囊神经性皮炎患者,按就诊前后顺序以单双数法分为联合组和对照组,两组共同给予0.1%他克莫司软膏外用,其中联合组同时给予口服帕罗西汀10mg∕d共8周治疗,于治疗8周后分别评估两组患者阴囊神经性皮炎主要症状、匹兹堡睡眠质量指数问卷评分。最后共67例患者完成观察。结果联合组与对照组痊愈率分别为54.3%(19∕35)、53.1%(17∕32),总有效率分别为82.9%(19∕35)、81.3%(26∕35)两组之间差异无统计学意义(P﹥0.05)。联合组与对照组痊愈后随访3个月的复发率分别为15.8%(3∕19)、47.1%(9∕17)。联合组痊愈后的复发率明显降低。两组比较差异有统计学意义(P<0.05)。匹兹堡睡眠质量指数评分治疗8周后联合组得分明显低于对照组,两组比较差异有统计学意义(P﹤0.05)。结论0.1%他克莫司软膏可以安全用于阴囊神经性皮炎。抗焦虑治疗可降低伴失眠的阴囊神经性皮炎的复发率,同时提高患者睡眠质量。
目的探討0.1%他剋莫司軟膏聯閤帕囉西汀治療陰囊神經性皮炎的臨床療效。方法選擇70例伴失眠的陰囊神經性皮炎患者,按就診前後順序以單雙數法分為聯閤組和對照組,兩組共同給予0.1%他剋莫司軟膏外用,其中聯閤組同時給予口服帕囉西汀10mg∕d共8週治療,于治療8週後分彆評估兩組患者陰囊神經性皮炎主要癥狀、匹玆堡睡眠質量指數問捲評分。最後共67例患者完成觀察。結果聯閤組與對照組痊愈率分彆為54.3%(19∕35)、53.1%(17∕32),總有效率分彆為82.9%(19∕35)、81.3%(26∕35)兩組之間差異無統計學意義(P﹥0.05)。聯閤組與對照組痊愈後隨訪3箇月的複髮率分彆為15.8%(3∕19)、47.1%(9∕17)。聯閤組痊愈後的複髮率明顯降低。兩組比較差異有統計學意義(P<0.05)。匹玆堡睡眠質量指數評分治療8週後聯閤組得分明顯低于對照組,兩組比較差異有統計學意義(P﹤0.05)。結論0.1%他剋莫司軟膏可以安全用于陰囊神經性皮炎。抗焦慮治療可降低伴失眠的陰囊神經性皮炎的複髮率,同時提高患者睡眠質量。
목적탐토0.1%타극막사연고연합파라서정치료음낭신경성피염적림상료효。방법선택70례반실면적음낭신경성피염환자,안취진전후순서이단쌍수법분위연합조화대조조,량조공동급여0.1%타극막사연고외용,기중연합조동시급여구복파라서정10mg∕d공8주치료,우치료8주후분별평고량조환자음낭신경성피염주요증상、필자보수면질량지수문권평분。최후공67례환자완성관찰。결과연합조여대조조전유솔분별위54.3%(19∕35)、53.1%(17∕32),총유효솔분별위82.9%(19∕35)、81.3%(26∕35)량조지간차이무통계학의의(P﹥0.05)。연합조여대조조전유후수방3개월적복발솔분별위15.8%(3∕19)、47.1%(9∕17)。연합조전유후적복발솔명현강저。량조비교차이유통계학의의(P<0.05)。필자보수면질량지수평분치료8주후연합조득분명현저우대조조,량조비교차이유통계학의의(P﹤0.05)。결론0.1%타극막사연고가이안전용우음낭신경성피염。항초필치료가강저반실면적음낭신경성피염적복발솔,동시제고환자수면질량。
Objective To evaluate the clinical efficiency of 0.1%tacrolimus ointment combined with paroxetine in patients with scrotal neurodermatitis associated with insomnia. Methods Totally,70 patients suffering from scrotal neurodermatitis and insomnia were consecutively enrolled in this study, and randomly assigned into the combination group and control group according to their number (odd or even).Both groups were given topical 0.1% tacrolimus ointment twice a day, and the combination group was additionally given oral paroxetine 10 mg once a day, for 8 weeks. The outcome parameters included main symptoms of neurodermatitis and Pittsburgh sleep quality index (PSQI) score. Pesults No significant difference was observsd in the cure rate (54.3%(19 35) vs. 53.1%(17 32), (P>0.05)) or response rate (82.9%(19 35) vs. 81.3%(26 32), (P>0.05)), between the combination group and control group. PSQI score was significantly lower in the combination group than in the control group after 8 weeks of treatment (P<0.05). Conclusions The 0.1% tacrolimus ointment can be used to treat scrotal neurodermatitis safely. Antianxiety treatment can reduce the recurrence of scrotal neurodermatitis associated with insomnia, and improve the quality of sleep in patients.