CAJ | 학술논문

目的了解河南输血感染的艾滋病患者和HIV携带者外周血T淋巴细胞亚群的表达。方法利用白细胞分类和流式细胞分析法对20例HIV携带者和20例AIDS患者外周血淋巴细胞中CD3+，CD4+，CD8+的表达及绝对数进行检测。结果 AIDS患者组CD3+淋巴细胞数较正常值显著下降（P<0.05）；HIV感染组与艾滋病组的CD4+ T淋巴细胞数显著下降（P<0.01）；CD8+淋巴细胞数显著增高（P<0.01）；CD4+/CD8+比值显著倒置。结论感染HIV后外周血CD4+ T淋巴细胞显著下降，随病情进展下降更显著。
목적료해하남수혈감염적애자병환자화HIV휴대자외주혈T림파세포아군적표체。방법이용백세포분류화류식세포분석법대20례HIV휴대자화20례AIDS환자외주혈림파세포중CD3+，CD4+，CD8+적표체급절대수진행검측。결과 AIDS환자조CD3+림파세포수교정상치현저하강（P<0.05）；HIV감염조여애자병조적CD4+ T림파세포수현저하강（P<0.01）；CD8+림파세포수현저증고（P<0.01）；CD4+/CD8+비치현저도치。결론감염HIV후외주혈CD4+ T림파세포현저하강，수병정진전하강경현저。
Objective To observe the expression of T lymphocyte subtype in peripheral blood of the people with AIDS or HIV infected by blood transfusion in Henan province. Methord Detect the expression of CD3+,CD4+,CD8+ and their absolute number in Peripheral blood of the people with AIDS or HIV infected by blood transfusion by leucocyte differential count and flow cytometry analysis. Results The number of CD3+ in people with AIDS decreased markedly than nomal(P<0.05), In people with AIDS or HIV , the number of CD4+ decreased markedly than nomal(P<0.01), the number of CD8+increased markedly than nomal(P<0.01), the proportion of CD4+/CD8+ inversed markedly. Conclusion The number of CD4+decreased markedly after the infection of HIV, and worsen with the progress of the disease