CAJ | 학술논문

目的观察奥沙利铂联合卡培他滨治疗晚期胃癌的疗效和安全性。方法21例晚期胃癌患者，静脉滴注奥沙利铂130mg/m2，d1；卡培他滨2500 mg/m2,分早晚2次口服，d1-14，21天为1周期。结果21例患者中，CR 2例，PR10例，SD3例，PD6例，近期有效率（CR+PR）为57.1%，中位生存期9个月，中位疾病进展时间为7个月。不良反应为手足综合征、神经毒性，多为Ⅰ-Ⅱ度。结论奥沙利铂联合卡培他滨化疗方案，缓解率高，能提高生活质量，毒副反应小，患者易耐受。
목적관찰오사리박연합잡배타빈치료만기위암적료효화안전성。방법21례만기위암환자，정맥적주오사리박130mg/m2，d1；잡배타빈2500 mg/m2,분조만2차구복，d1-14，21천위1주기。결과21례환자중，CR 2례，PR10례，SD3례，PD6례，근기유효솔（CR+PR）위57.1%，중위생존기9개월，중위질병진전시간위7개월。불량반응위수족종합정、신경독성，다위Ⅰ-Ⅱ도。결론오사리박연합잡배타빈화료방안，완해솔고，능제고생활질량，독부반응소，환자역내수。
Objective: To observe the efficacy and side efferts of oxalipatin plus capecitabine for the treatment of ad-vanced gastric cancer Methods: Twenty-one cases of patients . Oxaliplatin was given at a dose of 130mg/m2 by intravenous injection at day 1; Cape citabine was orally given at a dose of 2500 mg/m2, twice a day for two weeks. Twenty-one days was one cycle.Results: Among 21 patients , the response rate (CR+PR) was 57.1% with 2CR, 10PR, 3SD,6PD. MST was 9 months, mttp was 7 months. The major side effects were hand-foot syn-drome in 7(33.3%), newel toxity 12(57.1%), diarrhea 14 .conclusion: oxaplatin cornbined with capecitabine is a good chernother-appy with high clinical remission rate and could signiticartly improve life quality .And side effects could be tolerable.