CAJ | 학술논문

目的分析研究动员后PBMC治疗糖尿病其下肢动脉缺血性的疾病治疗机制以及疗效。方法选取2011年1月到2011年12月在本院接受治疗的糖尿病下肢动脉缺血性疾病的患者50例（为观察组），另外选取非糖尿病性的下肢动脉缺血性疾病患者60例（为对照组），接受研究的两组人员都行骨髓干细胞的动员后自体PBMC移植治疗。并计数两组动员之前与之后PBMC数以及CD34+，再观察研究两组治疗之前、治疗之后七天以及治疗之后四个月的临床疗效的评分（组织缺损、冷痛以及无痛行走距离、静息痛）。结果其两组人员治疗之后的四个月其组织缺损、冷痛以及无痛行走距离、静息痛的评分比质量之前更低，P小于0.05；观察组动员前PBMC治疗其糖尿病下肢动脉缺血性疾病其疗效显著。结论其动员后自体单个核细胞的移植对于治疗糖尿病性下肢动脉的缺血性疾病有着非常好的效果。
목적분석연구동원후PBMC치료당뇨병기하지동맥결혈성적질병치료궤제이급료효。방법선취2011년1월도2011년12월재본원접수치료적당뇨병하지동맥결혈성질병적환자50례（위관찰조），령외선취비당뇨병성적하지동맥결혈성질병환자60례（위대조조），접수연구적량조인원도행골수간세포적동원후자체PBMC이식치료。병계수량조동원지전여지후PBMC수이급CD34+，재관찰연구량조치료지전、치료지후칠천이급치료지후사개월적림상료효적평분（조직결손、랭통이급무통행주거리、정식통）。결과기량조인원치료지후적사개월기조직결손、랭통이급무통행주거리、정식통적평분비질량지전경저，P소우0.05；관찰조동원전PBMC치료기당뇨병하지동맥결혈성질병기료효현저。결론기동원후자체단개핵세포적이식대우치료당뇨병성하지동맥적결혈성질병유착비상호적효과。
Objective: analysis of disease treatment mechanism on the mobilization of PBMC treatment of diabetic lower extremity arterial ischemic and its effect. Methods: from 2011 January to 2011 December in our hospital to accept treatment of diabetic lower limb ischemia in 50 patients (observation group), in addition to select 60 cases of ischemic disease of the lower extremity arteries in patients with non diabetic (as control group), two groups accept of them bone marrow stem cell mobilization with PBMC transplantation. And count two before group mobilization and after PBMC and CD34+, and then study the treatment in the two groups before treatment, after scoring after seven days and the therapeutic effect in the treatment of four months (tissue defect of cold pain, and pain-free walking distance, rest pain). Results: four months after the treatment of the two groups of tissue defect of cold pain, and pain-free walking distance, rest pain score lower than quality before, P is less than 0.05; the observation group mobilization of PBMC treatment of diabetic lower limb arterial ischemic disease has significant effect. Conclusion: the autologous mononuclear cell transplantation for treatment of diabetic lower limb arterial ischemic disease has a very good effect.