CAJ | 학술논문

目的探讨美托洛尔联合卡维地洛治疗扩张型心肌病患者的疗效及安全性观察。方法随机将心内科收治的96例扩张型心肌病患者分为美托洛尔组，卡维地洛组，联合用药组，各32例。常规治疗基础上，美托洛尔组给予美托洛尔治疗，卡维地洛组给予卡维地洛治疗，联合用药组给予两种药物联合治疗。疗程16周，评价三组患者治疗后的心功能分级，左室收缩末期内径（LVESd）、左室舒张末期内径（LVEDd）、左心室射血分数（LVEF）及不良反应。结果美托洛尔组总有效率68.75%，卡维地洛组81.25%，联用组93.75%，三组比较具有显著差异，有统计学意义（P＜0.05）。三组均可明显改善扩心病左室收缩末期内径（LVESd）、左室舒张末期内径（LVEDd）、左心室射血分数（LVEF），但联用组优有单药使用，卡维地洛组优于美托洛尔组，差异有统计学意义（P＜0.05）。结论联用组治疗扩心病效果优于单药使用，卡维地洛组治疗效果优于美托洛尔组。
목적탐토미탁락이연합잡유지락치료확장형심기병환자적료효급안전성관찰。방법수궤장심내과수치적96례확장형심기병환자분위미탁락이조，잡유지락조，연합용약조，각32례。상규치료기출상，미탁락이조급여미탁락이치료，잡유지락조급여잡유지락치료，연합용약조급여량충약물연합치료。료정16주，평개삼조환자치료후적심공능분급，좌실수축말기내경（LVESd）、좌실서장말기내경（LVEDd）、좌심실사혈분수（LVEF）급불량반응。결과미탁락이조총유효솔68.75%，잡유지락조81.25%，련용조93.75%，삼조비교구유현저차이，유통계학의의（P＜0.05）。삼조균가명현개선확심병좌실수축말기내경（LVESd）、좌실서장말기내경（LVEDd）、좌심실사혈분수（LVEF），단련용조우유단약사용，잡유지락조우우미탁락이조，차이유통계학의의（P＜0.05）。결론련용조치료확심병효과우우단약사용，잡유지락조치료효과우우미탁락이조。
Objective :To evaluate the efficiency and safety of carvedilol combined with metoprolol in the treatment of dilated cardiomyopathy. Methods:96 patients with dilated cardiomyopathy admitted from department of cardiology were randomly divided into three groups:metoprolol group,carvedilol group,combined therapy group. On the basis of conventional treatment,metoprolol group were treated with metoprolol,carvedilol group were treated with carvedilol, combined therapy group were treated with two drugs above. Then compare the cardiac function,left ventricular ejection fraction (LVEF),left ventricular end-diastolic diameter(LVDd),left ventricular end-systolic diameter (LVSd) and adverse reactions between the three groups before and after treatment. Results:The total effective rate was 68.75%in metoprolol group,81.25% in carvedilol group,93.75% in combined therapy group,and there’s significant difference between the three groups(P<0.05). After treatment the cardiac function,left ventricular ejection fraction (LVEF),left ventricular end-diastolic diameter(LVDd),left ventricular end-systolic diameter (LVSd)of patients in the three groups were improved obviously. Use two drugs is better than one of them, and carvedilol is superior than metoprolol. There’ s significant difference between the three groups(P<0.05).Conclusion: Combined use two drugs is better than one of them, and carvedilol is superior than metoprolol.