中外健康文摘
中外健康文摘
중외건강문적
WORLD HEALTH DIGEST
2013年
22期
30-31
,共2页
阿托伐他汀%急性冠状动脉综合征%C反应蛋白
阿託伐他汀%急性冠狀動脈綜閤徵%C反應蛋白
아탁벌타정%급성관상동맥종합정%C반응단백
atorvastatin%Acute Coronary Syndrome%C reactive protein
目的探讨阿托伐他汀对急性冠状动脉综合征患者血清C反应蛋白的影响。方法选择急性冠状动脉综合征患者54人,随机分为阿伐他汀组和常规治疗组,阿伐他汀组在常规治疗的基础上加用阿托伐他汀每天40mg,常规治疗组采用常规治疗。分别于治疗前和治疗后两周测定血清C反应蛋白和血脂水平,比较其差异。结果54例急性冠状动脉综合征患者中,不稳定心绞痛21例,急性心肌梗死33例。血清C反应蛋白水平,心绞痛者为1.35±0.54 g/L,心肌梗死者2.25±0.43g/L,均高于正常对照组的0.29±0.23 g/L(P<0.05),心肌梗死患者较心绞痛者C反应蛋白升高显著(P<0.05)。阿托伐他汀治疗两周,血清C反应蛋白水平由1.86±0.43g/L降至0.51±0.23g/L,治疗前后相比有显著性差异(P<0.05)。常规治疗组血清C反应蛋白水平由1.82±0.50 g/L降至1.74±0.60 g/L,治疗前后相比无显著性差异(P>0.05)。结论 C反应蛋白可能参与动脉粥样硬化的形成,短期使用阿托伐他汀即能明显降低急性冠状动脉综合征患者的血浆C反应蛋白水平,提示阿托伐他汀调脂作用之外还有抗炎作用。
目的探討阿託伐他汀對急性冠狀動脈綜閤徵患者血清C反應蛋白的影響。方法選擇急性冠狀動脈綜閤徵患者54人,隨機分為阿伐他汀組和常規治療組,阿伐他汀組在常規治療的基礎上加用阿託伐他汀每天40mg,常規治療組採用常規治療。分彆于治療前和治療後兩週測定血清C反應蛋白和血脂水平,比較其差異。結果54例急性冠狀動脈綜閤徵患者中,不穩定心絞痛21例,急性心肌梗死33例。血清C反應蛋白水平,心絞痛者為1.35±0.54 g/L,心肌梗死者2.25±0.43g/L,均高于正常對照組的0.29±0.23 g/L(P<0.05),心肌梗死患者較心絞痛者C反應蛋白升高顯著(P<0.05)。阿託伐他汀治療兩週,血清C反應蛋白水平由1.86±0.43g/L降至0.51±0.23g/L,治療前後相比有顯著性差異(P<0.05)。常規治療組血清C反應蛋白水平由1.82±0.50 g/L降至1.74±0.60 g/L,治療前後相比無顯著性差異(P>0.05)。結論 C反應蛋白可能參與動脈粥樣硬化的形成,短期使用阿託伐他汀即能明顯降低急性冠狀動脈綜閤徵患者的血漿C反應蛋白水平,提示阿託伐他汀調脂作用之外還有抗炎作用。
목적탐토아탁벌타정대급성관상동맥종합정환자혈청C반응단백적영향。방법선택급성관상동맥종합정환자54인,수궤분위아벌타정조화상규치료조,아벌타정조재상규치료적기출상가용아탁벌타정매천40mg,상규치료조채용상규치료。분별우치료전화치료후량주측정혈청C반응단백화혈지수평,비교기차이。결과54례급성관상동맥종합정환자중,불은정심교통21례,급성심기경사33례。혈청C반응단백수평,심교통자위1.35±0.54 g/L,심기경사자2.25±0.43g/L,균고우정상대조조적0.29±0.23 g/L(P<0.05),심기경사환자교심교통자C반응단백승고현저(P<0.05)。아탁벌타정치료량주,혈청C반응단백수평유1.86±0.43g/L강지0.51±0.23g/L,치료전후상비유현저성차이(P<0.05)。상규치료조혈청C반응단백수평유1.82±0.50 g/L강지1.74±0.60 g/L,치료전후상비무현저성차이(P>0.05)。결론 C반응단백가능삼여동맥죽양경화적형성,단기사용아탁벌타정즉능명현강저급성관상동맥종합정환자적혈장C반응단백수평,제시아탁벌타정조지작용지외환유항염작용。
Aim To approach the effect of atorvastatin on C reactive protein(CRP)of patient with acute coronary syn-drome(ACS). Methods 54 cases with ACS,which were determined CRP level pre-and pos-t treatment two weeks,respec-tively,and compared its difference,were randomly divided into therapeutic drug group and control group,therapeutic group wastreated with atorvastatin 40mg daily based on routine treatment(control group). Results 54 cases include 21 cases unstable angina and 33 cases acute myocardial infarction. The CRP levelwas 1.35±0.54 g/L, in angina patient andwas 2.25±0.43g/L, in the patientwith acute myocardial infarction. And itwere higherthan that of normal control(0.30±0.22 g/L)(P<0.05),it was significant advanced of CRP in the patientwith myocardial infarction than that of the patientwith angina(P<0.05). Theblood serum CRP level decreased from 1.86±0.43g/L to 0.51±0.23g/L (P<0.05) in therapeutic group and has no changes in the control group of the blood serum CRP level decreased from 1.82±0.50 g/L to 1.74±0.60 g/L (P﹥0.05). Con-clusion The CRP is possible to participate the formation of atherosclerosis,and the CRP level was set down obviously of the pa-tients with ACS,it is shown that the atorvastatin can reduce lipid besides ant-i inflammatory effect.
