CAJ | 학술논문

目的观察曲美他嗪联合倍他乐克治疗慢性充血性心衰（CHF）的临床疗效。方法选择心衰患者76例，随机分为两组，对照组（38例）给予利尿剂、血管扩张剂血管紧张素转换酶抑制剂、洋地黄制剂等常规治疗；治疗组（38例），在治疗组中加用曲美他嗪（3次/天，20mg/次，疗程6个月）及倍他乐克（2次/天，12.5mg~25mg/次，疗程6个月）。结果治疗组心功能改善有效率为89%，明显高于对照组的60%。治疗前后对比，治疗组心率、血压、左室射血分数、左室舒张末期容积、左室收缩末期容积、6分钟步行试验均有显著改善，治疗组与对照组比较差异有统计学意义（P<0.05）。结论用曲美他嗪联合倍他乐克治疗慢性心衰是一种安全有效的方法。
목적관찰곡미타진연합배타악극치료만성충혈성심쇠（CHF）적림상료효。방법선택심쇠환자76례，수궤분위량조，대조조（38례）급여이뇨제、혈관확장제혈관긴장소전환매억제제、양지황제제등상규치료；치료조（38례），재치료조중가용곡미타진（3차/천，20mg/차，료정6개월）급배타악극（2차/천，12.5mg~25mg/차，료정6개월）。결과치료조심공능개선유효솔위89%，명현고우대조조적60%。치료전후대비，치료조심솔、혈압、좌실사혈분수、좌실서장말기용적、좌실수축말기용적、6분종보행시험균유현저개선，치료조여대조조비교차이유통계학의의（P<0.05）。결론용곡미타진연합배타악극치료만성심쇠시일충안전유효적방법。
Objective To explore the clinical effect ofcombination of Trimetazidine and Bataloc on chronic congestive heart failure(CHF).Methods seventy-six patientsWith CHF were divided into two groups randomly.In control group,38 patients wereTreated with routine medicine ,such as digitalis ,diuretic agent,vasodilating Agent,angiotensin converting enzyme inhibitor(ACEI),etc.38 patients in treatmentgroup were added with Trimetazidine and Bataloc.Results the response rate was89% in treatment group, much higher than that of 60.0% in control group(P<0.05).Compared with which before treatment,there were much improvements in the heart rate,blood pressure,left ventricular ejection fraction,left ventricular end diastolic volume,left wentricular end-systolic volume and Six-minute Walking Test in treatment group,and the differents between the two guoups were statiscally significant.Conclusions It is a saft and effective method in treating chronic CHF with combination of Trimetazidine and Bataloc.