CAJ | 학술논문

目的分析晚期癌痛患者，行姑息性镇静治疗，评价其痛苦症状控制情况。分析镇静治疗的可行性和有效性。方法选择来我院治疗的晚期癌症难治性疼痛患者48例，预计生存期较短。实验采用交叉设计的方差分析，将研究对象随机分为2组，每Ⅱ组24例，第一阶段：Ⅰ组维持基础吗啡剂量不变，增加注射用吗啡剂量1 mg/kg，同时加用咪达唑仑注射液0.2mg/kg，Ⅱ组维持基础吗啡剂量不变增加注射用吗啡剂量1 mg/kg，用药时间为一周；经24小时的洗脱期后，进入第二阶段。第二阶段：Ⅰ组维持基础吗啡剂量不变，加用注射用吗啡剂量1 mg/kg，Ⅱ组维持基础吗啡剂量不变、加用咪达唑仑注射液0.2mg/kg及注射用吗啡剂量1 mg/kg。结果1、病例基本特征分布情况的统计分析，是均衡分布的，两组具有良好的可比性；2、单用吗啡和吗啡联合镇静两种方法对难治性疼痛镇痛效能的比较，取P<0.05为差异具有统计学意义。结论吗啡联合镇静药对癌症难治性疼痛的镇痛效果明显优于单用吗啡。
목적분석만기암통환자，행고식성진정치료，평개기통고증상공제정황。분석진정치료적가행성화유효성。방법선택래아원치료적만기암증난치성동통환자48례，예계생존기교단。실험채용교차설계적방차분석，장연구대상수궤분위2조，매Ⅱ조24례，제일계단：Ⅰ조유지기출마배제량불변，증가주사용마배제량1 mg/kg，동시가용미체서륜주사액0.2mg/kg，Ⅱ조유지기출마배제량불변증가주사용마배제량1 mg/kg，용약시간위일주；경24소시적세탈기후，진입제이계단。제이계단：Ⅰ조유지기출마배제량불변，가용주사용마배제량1 mg/kg，Ⅱ조유지기출마배제량불변、가용미체서륜주사액0.2mg/kg급주사용마배제량1 mg/kg。결과1、병례기본특정분포정황적통계분석，시균형분포적，량조구유량호적가비성；2、단용마배화마배연합진정량충방법대난치성동통진통효능적비교，취P<0.05위차이구유통계학의의。결론마배연합진정약대암증난치성동통적진통효과명현우우단용마배。
Objective To analyze the patients with advanced cancer, who are in refractory pain and treated with palliative sedation. During the therapy we assess the relief of the intractable pain and other anguish symptoms and analyze the feasibility and validity of the home sedation therapy.Methods we choose to come to our hospital for medical treatment in 48 patients who is dying. the subjects were randomly divided into 2 groups of 24 cases, the first stage: Group 1 to maintain the same dose of morphine base, at the same time,to increase the injection of morphine dose 1 mg / kg, and midazolam injection 0.2mg/kg,group 2 to maintain the same dose of morphine based on additional injection of morphine dose of 1 mg / kg, administration time of the week; by a 24-hour washout period, after the second stage. The second stage: Group 1 to maintain the same dose of morphine base, plus injection of morphine dose 1 mg / kg, group 2 to maintain the same dose of morphine base, plus midazolam injection o.2mg/kg dose and the injection of morphine dose of 1 mg / kg. Results 1. the statistical analysis of the distribution of the basic characteristics about the type of pain, cancer treatment history, age, weight, dose of morphine base,it is evenly distributed in the two groups, the two groups have good comparability. 2. This study compared to two ways that morphine and morphine combinati with sedatives to treat the refractory pain .using SPSS15.0 statistical software analysis result of analgesic efficacy in two ways, P <0.01, statistically significant difference.Conclusions 1. Morphine combinating with sedative on the analgesic effect about refractory cancer pain,it is superior than single using morphine