CAJ | 학술논문

目的观察白三烯拮抗剂对敏性鼻炎Th1/Th2的影响。方法选择在本院变态反应（过敏）科就诊87例,随机分为2组，治疗组44例，对照组43例，所有患者均给予氯雷他定抗过敏,治疗组加用孟鲁司特钠片口服每日一次,3月为一疗程。观察两组患者鼻部症状改善的情况，并检测血清IL-4、IL-5、IFN-γ的变化。结果治疗组患者症状明显改善,血清IL-4、IL-5明显下降，IFN-γ升高。结论白三烯拮抗剂能有效治疗过敏性鼻炎，并纠正过敏性鼻炎的 Th1/Th2免疫失衡。
목적관찰백삼희길항제대민성비염Th1/Th2적영향。방법선택재본원변태반응（과민）과취진87례,수궤분위2조，치료조44례，대조조43례，소유환자균급여록뢰타정항과민,치료조가용맹로사특납편구복매일일차,3월위일료정。관찰량조환자비부증상개선적정황，병검측혈청IL-4、IL-5、IFN-γ적변화。결과치료조환자증상명현개선,혈청IL-4、IL-5명현하강，IFN-γ승고。결론백삼희길항제능유효치료과민성비염，병규정과민성비염적 Th1/Th2면역실형。
Objective: To observe the effect of leukotriene receptor antagonist Th1/Th2 on allergic rhinitis.Method:Choice reaction in our hospital during metamorphosis (allergic) treatment in 87 cases, Were randomly divided into 2 groups, 44 cases in treatment group, 43 cases in the control group, All patients were given loratadine allergy, The treatment group was treated with montelukast sodium tablets once daily, March for a course of treatment. Observation of nasal symptoms in the patients of two groups to improve the situation, and to detect the changes of serum IL-4, IL-5, IFN- γ.Results: The treatment group patients symptoms improved significantly, serum IL-4, IL-5 decreased significantly, IFN- γ increased. Conclusion: Leukotriene receptor antagonist, is effective in the treatment of allergic rhinitis, Th1/Th2 immune imbalance and correct the allergic rhinitis