CAJ | 학술논문

目的观察隔日1次口服地高辛0.125mg治疗老年慢性充血性心力衰竭﹙ CHF﹚的临床疗效及安全性。方法选择2010年1月至2013年1月在我科住院的92例为观察对象，随机分为地高辛治疗组﹙A组﹚和常规对照组﹙B组﹚各46例，两组年龄、性别、病程、基础疾病构成等临床基线有可比性，两组采用相同的基础治疗，治疗组予隔日1次口服地高辛0.125 mg，疗程2个月，比较两组患者治疗后的有效率及6min 步行距离、心率情况，观察洋地黄中毒发生情况。结果1.临床疗效比较：A、B两组总有效率分别为86.9％和65.2％。A组明显优于B组﹙P<O.05﹚。2两组患者6min步行距离及心率均有改善，而治疗组优于对照组﹙P<O.05﹚，治疗组无患者因发生洋地黄中毒退出观察、治疗。结论隔日小剂量地高辛治疗老年CHF 安全、有效。
목적관찰격일1차구복지고신0.125mg치료노년만성충혈성심력쇠갈﹙ CHF﹚적림상료효급안전성。방법선택2010년1월지2013년1월재아과주원적92례위관찰대상，수궤분위지고신치료조﹙A조﹚화상규대조조﹙B조﹚각46례，량조년령、성별、병정、기출질병구성등림상기선유가비성，량조채용상동적기출치료，치료조여격일1차구복지고신0.125 mg，료정2개월，비교량조환자치료후적유효솔급6min 보행거리、심솔정황，관찰양지황중독발생정황。결과1.림상료효비교：A、B량조총유효솔분별위86.9％화65.2％。A조명현우우B조﹙P<O.05﹚。2량조환자6min보행거리급심솔균유개선，이치료조우우대조조﹙P<O.05﹚，치료조무환자인발생양지황중독퇴출관찰、치료。결론격일소제량지고신치료노년CHF 안전、유효。
Objective To observe the clinical efficacy and safety of digoxin at 0. 125 mg oral dose every other day in treatment of elderly patients with chronic congestive heart failure (CHF). Methods 92 cases of inpatients in our department selected from January 2010 to January 2013 were randomly divided into digoxin treatment group (A) and normal control group (B group), 46 cases each. Two groups had comparability in age, gender, disease duration and so forth constituting the underlying disease clinical baseline and were subject to the same basic treatment with the treatment group orally given 125 mg digoxin every other day for a course of 2 months. The comparison was made between two groups after the treatment in efficiency, 6min walking distance, and heart, and the observation made on digitalis intoxication. Results 1. Clinical efficacy comparison: For A and B groups, total efficiency was 86.9% and 65.2%, respectively. A group was significantly better than in group B (P <O.05). 2. For the two groups of patients, 6min walking distance and heart rate were improved with the treatment group better than the control group (P <O.05); also, the treatment group had no patients who exited from the treatment and observation due to occurrence of digitalis toxicity. Conclusion A small dose of digoxin given every other day is safe and effective in treatment of CHF in elderly patients.