CAJ | 학술논문

目的探讨二甲双胍联合罗格列酮治疗多囊卵巢综合征的临床疗效.方法随机选取2011年12月至2012年2月入我院治疗的40例多囊卵巢综合征患者的临床资料,对其给予二甲双胍和罗格列酮联合治疗三个月后,统计和分析比较患者治疗前后黄体生成激素、空腹胰岛素、睾酮、空腹血糖的变化情况.结果本组40例多囊卵巢综合征患者经二甲双胍联合罗格列酮治疗后,患者的月经不规律、痤疮、多毛症状均减轻,其中有33例月经周期恢复正常,有8例出现胃肠轻度不适反应.治疗后LH、FINS、T及FPG水平较治疗前均有不同程度的下降,P<0.05,治疗前后差异有统计学意义.结论治疗多囊卵巢综合征时应用二甲双胍和罗格列酮联合治疗可以使患者的卵巢功能得到有效改善,效果显著,无明显副作用,在临床可推广使用.
목적탐토이갑쌍고연합라격렬동치료다낭란소종합정적림상료효.방법수궤선취2011년12월지2012년2월입아원치료적40례다낭란소종합정환자적림상자료,대기급여이갑쌍고화라격렬동연합치료삼개월후,통계화분석비교환자치료전후황체생성격소、공복이도소、고동、공복혈당적변화정황.결과본조40례다낭란소종합정환자경이갑쌍고연합라격렬동치료후,환자적월경불규률、좌창、다모증상균감경,기중유33례월경주기회복정상,유8례출현위장경도불괄반응.치료후LH、FINS、T급FPG수평교치료전균유불동정도적하강,P<0.05,치료전후차이유통계학의의.결론치료다낭란소종합정시응용이갑쌍고화라격렬동연합치료가이사환자적란소공능득도유효개선,효과현저,무명현부작용,재림상가추엄사용.
Objective: To investigate the clinical efficacy of metformin plus rosiglitazone treatment of polycystic ovary syndrome. Methods: A December 2011 to February 2012 into ourhospital,40 cases of polycystic ovary syndrome patients with clinical data to give them the metformin and rosiglitazone combination therapy for three months, statistics and analysis patients before and after luteinizinghormone, fasting insulin, testosterone, fasting blood glucose changes. Results: This group of 40 patients with polycystic ovary syndrome by metformin, rosiglitazone therapy, the patients with menstrual irregularity, acne,hirsutism symptoms are reduced, including 33 cases of menstrual cycle returned to normal, there are eight cases of gastrointestinal response of mild discomfort. Treatmenthave different degrees of decline in LH, FINS and T and the FPG level than before treatment, P<0.05, before and after treatment difference was statistically significant. Conclusion: The application of metformin and rosiglitazone combination therapy in the treatment of polycystic ovary syndrome can make the patient's ovarian functionhas been effectively improved, the effect is significant, no significant side effects in clinical practice to promote the use of