CAJ | 학술논문

目的观察孟鲁司特钠(顺尔宁)对慢性阻塞性肺疾病(COPD)稳定期患者症状和肺功能的影响。方法48例患者随机分为观察组(孟鲁司特钠)和对照组各24例。两组经2周洗脱期后,均予相同治疗,观察组同时加用孟鲁司特钠片10m g,每晚口服一次,疗程8周。观察两组治疗前后肺功能和症状变化。结果两组治疗前肺功能无明显差异；治疗后两组肺功能较治疗前均有显著改善。观察组较对照组用药前后用力肺活量(FVC),第一秒用力呼气容积(FEV1),第一秒用力呼气容积占预计值的百分比(FEV1%)明显改善,差异有显著性。结论孟鲁司特钠对COPD稳定期患者肺功能有显著的改善作用。
목적관찰맹로사특납(순이저)대만성조새성폐질병(COPD)은정기환자증상화폐공능적영향。방법48례환자수궤분위관찰조(맹로사특납)화대조조각24례。량조경2주세탈기후,균여상동치료,관찰조동시가용맹로사특납편10m g,매만구복일차,료정8주。관찰량조치료전후폐공능화증상변화。결과량조치료전폐공능무명현차이；치료후량조폐공능교치료전균유현저개선。관찰조교대조조용약전후용력폐활량(FVC),제일초용력호기용적(FEV1),제일초용력호기용적점예계치적백분비(FEV1%)명현개선,차이유현저성。결론맹로사특납대COPD은정기환자폐공능유현저적개선작용。
Objective To investigate the effect ofmontelukast sodium on symptoms and pulmonary function of tranquilization period of chronic obstructive pulmonarydisease(COPD).Methods 48 patients with COPD were randomlydivided into twogroups: trialgroup (24 cases) and controlgroup (24 cases).After two weeks≧ washout stage, bothgroups received the same therapy, but the patients at trialgroup were additionallygiven 10mgmontelukast sodium q.n for 8 weeks.The change of pulmonary function and symptoms on eachgroup were observed before and 8 weeks after therapy.Results Before the treatment, pulmonary function in the bothgroups were not statisticallydifferent(P>0.05).After the treatment, there was improvement of pulmonary function than before the treatment (P<0.05).FVC, FEV1 and FEV1% Pred were superior in the trialgroup to the controlgroup.Conclusion montelukast sodium can improve pulmonary function significantly of tranquilization period of chronic obstructive pulmonarydisease(COPD).