CAJ | 학술논문

目的观察不稳定型心绞痛(UA)发生后24h内应用不同剂量阿托伐他汀的疗效与安全性。方法将120例UA患者随机分为两组,分别给予阿托伐他汀20mg/d与40mg/d,用药4周后观察两组患者血脂达标情况、高敏C-反应蛋白(hs-CRP)、心血管事件的发生率及药物不良反应。结果(1)两组治疗l个月后的总胆固醇(TC)、低密度脂蛋白(LDL)、hs-CRP水平均明显降低,且40mg/d组在各时间段血脂达标情况优于20mg/d组,住院及随访期间心脏事件发生率也明显减少；(2)两组均未见明显不良反应。结论 ACS患者应用20mg/d及40mg/d的阿托伐他汀均能有效降脂,40mg/d辛伐他汀调脂及减少心血管事件更佳,且治疗过程中无严重不良反应。
목적관찰불은정형심교통(UA)발생후24h내응용불동제량아탁벌타정적료효여안전성。방법장120례UA환자수궤분위량조,분별급여아탁벌타정20mg/d여40mg/d,용약4주후관찰량조환자혈지체표정황、고민C-반응단백(hs-CRP)、심혈관사건적발생솔급약물불량반응。결과(1)량조치료l개월후적총담고순(TC)、저밀도지단백(LDL)、hs-CRP수평균명현강저,차40mg/d조재각시간단혈지체표정황우우20mg/d조,주원급수방기간심장사건발생솔야명현감소；(2)량조균미견명현불량반응。결론 ACS환자응용20mg/d급40mg/d적아탁벌타정균능유효강지,40mg/d신벌타정조지급감소심혈관사건경가,차치료과정중무엄중불량반응。
Objective To observe theUnstable angina (UA)occurred within 24hours after application ofdifferentdoses of atorvastatin efficacy and safety.Methods Onehundred and twenty patients withUA were randomlydivided into 2groups weregiven within 24hours of atorvastatin 20mg and 40mg once everyday.medication 4 weeks observation of twogroups lipid compliance andhigh sensitivity C-reactive protein(hs-CRP)and cardiovascular events in the incidence and adversedrug reactions.Results (1) Twogroups therapy 4 weeks total cholesterol(TC),lowdensity lipoprotein(LDL),hs-CRP were significantly reduced,and the 40mggroup than in 20mggroup in within 4 weeks was better than 20mg of lipid compliancegroup,hospitalization and incidence of cardiac eventsduring follow -up is also significantly 'reduced;(2) Twogroups were no adverse reactions.Conclusion UA patients with 20mg/dand 40mg/dof atorvastatin can be effective lipid lowering,mg/dof atorvastatin on lipid and to reduce cardiovascular events better,and the course of treatment without serious adverse reactions.