CAJ | 학술논문

目的比较肝动脉化疗栓塞(TACE)结合三维适形放射治疗(3DCRT)与单纯介入肝动脉化疗栓塞(TACE)对原发性肝癌(PHC)的疗效.方法56例PHC患者分为2个组,A组28例(3DCRT+TACE,先TACE1~3次,3DCRT45~60Gy),B组28例(TACE2~3次).介入化疗选用顺铂60~100mg、阿霉素40mg、丝裂霉素20mg或5-FU1000~1500mg,顺铂60~80mg,ADM40mg(或MMC10~20mg).放射源为BJ-6B6MVX线直线加速器.结果有效率A组CR+PR27例,总有效率为96%；B组CR+PR17例,总有效率为60.7%(P<0.01).并发症主要为发热,白细胞下降,肝功能不全,急性胃肠道反应.癌灶体积与疗效有关,PTV≤216cm3者完全缓解(CR)7/8, PTV>216cm3者CR为1/8(P<0.01).结论 PHC疗效3DCRT+TACE优于单纯TACE.并发症主要是发热、白细胞下降和肝功能不全,急性胃肠道反应.
목적비교간동맥화료전새(TACE)결합삼유괄형방사치료(3DCRT)여단순개입간동맥화료전새(TACE)대원발성간암(PHC)적료효.방법56례PHC환자분위2개조,A조28례(3DCRT+TACE,선TACE1~3차,3DCRT45~60Gy),B조28례(TACE2~3차).개입화료선용순박60~100mg、아매소40mg、사렬매소20mg혹5-FU1000~1500mg,순박60~80mg,ADM40mg(혹MMC10~20mg).방사원위BJ-6B6MVX선직선가속기.결과유효솔A조CR+PR27례,총유효솔위96%；B조CR+PR17례,총유효솔위60.7%(P<0.01).병발증주요위발열,백세포하강,간공능불전,급성위장도반응.암조체적여료효유관,PTV≤216cm3자완전완해(CR)7/8, PTV>216cm3자CR위1/8(P<0.01).결론 PHC료효3DCRT+TACE우우단순TACE.병발증주요시발열、백세포하강화간공능불전,급성위장도반응.
Objective To compare the effects of transcatheter arterial chemoembolization(TACE) combined with 3dimensional conformal radiation therapy(3DCRT) and TACE for primary hepatic cancer(PHC) Methods 56 patients with PHC were randomized to two groups: GroupⅠ-28 patients,TACE plus 3DCRT,received 1~3 times of TACE followed by radiotherapy;GroupⅡ-28 patients only received 1~3 times of TACE. For interventional chemotherapy,the treatment regimen consisted of the combination of the following 60~100mg cisplatin 40mg adriamycin and 20mg mitomycin or 1000~1500mg 5-fluorouracil,60~80mg cisplatin and 40mg adriamycin/10~20mg mitomycin. Radiotherapy was given by electron linear accelerator Results The overall response rate of 3DCRT plus TACE was 96%; For TACE alone the overall response rate was 60.7%(P<0.01). The main complication was fever conclution Treatment result of 3DCRT plus TACE is better than that of TACE alone.