CAJ | 학술논문

目的探讨创伤性休克患者早期血小板(PLT)及凝血功能演变规律,为指导早期治疗提供参考.方法选择创伤性休克患者96例,分别于入院时、入院后6h、入院后24h采外周静脉血,检测PLT、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原FIB),另选择40例健康人作对照组.结果创伤性休克组与正常对照组比较,PLT在及从入院时在正常范围内,入院后6h开始下降,24h下降明显,差异有统计学意义(P<0.01)； PT、APTT在入院时及入院后6h开始延长,入院后24h明显延长,差异有统计学意义(P<0.05)； TT在入院时到入院后6h均在正常范围内,入院后24h增加,差异有统计学意义(P<0.05)；FIB在创伤性休克组各时间点均有下降,差异有统计学意义(P<0.01).结论创伤性休克患者在早期即出现凝血功能受损,并在24h内呈动态改变,动态监测创伤性休克患者的血小板和凝血功能,对评估伤情、判断预后和指导早期治疗具有重要的临床意义.
목적탐토창상성휴극환자조기혈소판(PLT)급응혈공능연변규률,위지도조기치료제공삼고.방법선택창상성휴극환자96례,분별우입원시、입원후6h、입원후24h채외주정맥혈,검측PLT、응혈매원시간(PT)、활화부분응혈활매시간(APTT)、응혈매시간(TT)、섬유단백원FIB),령선택40례건강인작대조조.결과창상성휴극조여정상대조조비교,PLT재급종입원시재정상범위내,입원후6h개시하강,24h하강명현,차이유통계학의의(P<0.01)； PT、APTT재입원시급입원후6h개시연장,입원후24h명현연장,차이유통계학의의(P<0.05)； TT재입원시도입원후6h균재정상범위내,입원후24h증가,차이유통계학의의(P<0.05)；FIB재창상성휴극조각시간점균유하강,차이유통계학의의(P<0.01).결론창상성휴극환자재조기즉출현응혈공능수손,병재24h내정동태개변,동태감측창상성휴극환자적혈소판화응혈공능,대평고상정、판단예후화지도조기치료구유중요적림상의의.
Objective To explore the traumatic shock in patients with early platelet (PLT) and coagulation evolution, provide a reference for guiding early treatment. Methods 96 cases of patients with traumatic shock, respectively, at the time of admission,6 hours after admission,24 hours after admission collected peripheral venous blood, the detection of the PLT, the prothrombin time (PT), activated partial thromboplastin enzyme time (APTT), thrombin time (TT), fibrinogen FIB) in another 40 healthy subjects as control group. The results of the traumatic shock group and normal control group, PLT and from the time of admission in the normal range within 6 hours after admission, began to decline,24h significantly decreased, the difference was statistically significant (P <0.01); PT and APTT on admission and 6 hours after admission, extension,24 hours after admission was significantly prolonged, the difference was statistically significant (P <0.05); TT in the time of admission to 6 hours after admission were within the normal range,24 hours after admission increase, the difference was statistically significant (P <0.05); the FIB in the traumatic shock group at each time point were decreased, the difference was statistically significant (P <0.01). Conclusions of traumatic shock patients at an early stage of coagulation dysfunction, and dynamic changes within 24h, Dynamic monitoring of platelets and clotting function of patients with traumatic shock, injury assessment, prognosis and guide early treatment has clinical significance .